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    myh11.L myosin heavy chain 11 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 495286, updated on 27-Dec-2024

    Summary

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    Official Symbol
    myh11.L
    Official Full Name
    myosin heavy chain 11 L homeolog
    Primary source
    Xenbase:XB-GENE-17331273
    Locus tag
    XELAEV_18045183mg
    See related
    EnsemblRapid:ENSXLAG00005015017 AllianceGenome:Xenbase:XB-GENE-17331273
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    aat4; faa4; smhc; smmhc; sm-mhc
    Summary
    Predicted to enable several functions, including ATP binding activity; actin filament binding activity; and calmodulin binding activity. Predicted to be located in myosin filament. Predicted to be part of myosin complex. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome; patent ductus arteriosus; and thoracic aortic aneurysm. Orthologous to human MYH11 (myosin heavy chain 11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See myh11.L in Genome Data Viewer
    Location:
    chromosome: 9_10L
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (102039896..102099373, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (91462770..91523159, complement)

    Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene meiosis regulator and mRNA stability factor 1 L homeolog Neighboring gene nudE neurodevelopment protein 1 L homeolog Neighboring gene centrosomal protein 20 L homeolog Neighboring gene ATP binding cassette subfamily C member 1 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin-11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      102039896..102099373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018236332.2 → XP_018091821.1  myosin-11 isoform X2

      UniProtKB/TrEMBL
      A0A8J0TNE1
      Related
      ENSXLAP00005044026.1, ENSXLAT00005045098.1

    2. XM_041577521.1 → XP_041433455.1  myosin-11 isoform X1

      UniProtKB/TrEMBL
      A0A8J1LXH5
      Related
      ENSXLAP00005044017.1, ENSXLAT00005045089.1
      Conserved Domains (3) summary
      COG1196
      Location:1112 → 1935
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5022
      Location:35 → 1483
      COG5022; Myosin heavy chain [General function prediction only]
      cd14921
      Location:98 → 777
      MYSc_Myh11; class II myosin heavy chain 11, motor domain

    3. XM_041577522.1 → XP_041433456.1  myosin-11 isoform X3

      UniProtKB/TrEMBL
      A0A1L8EXL3, A0A974H4G2
      Related
      ENSXLAP00005044005.1, ENSXLAT00005045077.1
      Conserved Domains (3) summary
      cd14921
      Location:98 → 777
      MYSc_Myh11; class II myosin heavy chain 11, motor domain
      pfam01576
      Location:854 → 1934
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:32 → 71
      Myosin_N; Myosin N-terminal SH3-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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