krt12.4.L Keratin 12, gene 4 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: krt12.4.L
Official Full Name: Keratin 12, gene 4 L homeolog
Primary source: Xenbase:XB-GENE-6255484
Locus tag: XELAEV_18043119mg
See related: EnsemblRapid:ENSXLAG00005030544 AllianceGenome:Xenbase:XB-GENE-6255484
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: EpK; K81; EpiK; ck81; xK81; cytok; xk81a; epiker; xk81a1; xk81a1.L; E-keratin; cytokeratin; epi-keratin
Summary: Predicted to enable structural molecule activity. Predicted to act upstream of or within epithelial cell differentiation and intermediate filament organization. Predicted to be located in intermediate filament. Is expressed in dermal system; ectoderm; and visual system. Human ortholog(s) of this gene implicated in Meesmann corneal dystrophy 1 and corneal dystrophy. Orthologous to human KRT12 (keratin 12). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (1279716..1283328)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (1247794..1251407)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The structural function of VegT mRNA in Xenopus oocyte depends on its combinatory signals for the induction or facilitation and for the maintenance of the depolymerization vs. polymerization status of cytokeratin filaments.
Title: Structural messenger RNA contains cytokeratin polymerization and depolymerization signals.
Sequential deletion analyses revealed that the regions proximal to the type I keratin promoter were essential for fin-specific expression.
Title: Characterization of a novel type I keratin gene and generation of transgenic lines with fluorescent reporter genes driven by its promoter/enhancer in Xenopus laevis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intermediate filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: keratin, type I cytoskeletal 47 kDa

Names: Epidermis-specific keratin; Keratin, type I cytoskeletal 47 kDa L homeolog; epidermal keratin type 1; gastrula stage epidermal type I cytokeratin; type I epidermal keratin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.