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    serpina1.S serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 379963, updated on 27-Dec-2024

    Summary

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    Official Symbol
    serpina1.S
    Official Full Name
    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog
    Primary source
    Xenbase:XB-GENE-5804592
    Locus tag
    XELAEV_18041293mg
    See related
    EnsemblRapid:ENSXLAG00005003716 AllianceGenome:Xenbase:XB-GENE-5804592
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    a1a; a1at; alpha1AT; serpina1; serpina1d
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; chronic obstructive pulmonary disease (multiple); human immunodeficiency virus infectious disease; inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human SERPINA1 (serpin family A member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See serpina1.S in Genome Data Viewer
    Location:
    chromosome: 8S
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (20153701..20162618)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (20058412..20075177)

    Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene goosecoid homeobox S homeolog Neighboring gene uncharacterized LOC121397679 Neighboring gene alpha-1-antiproteinase-like Neighboring gene protein phosphatase 4, regulatory subunit 4 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC64429

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog
    Names
    serine (or cysteine) proteinase inhibitor, clade A, member 1d

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001086802.2 → NP_001080271.1  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog precursor

      See identical proteins and their annotated locations for NP_001080271.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054235
      UniProtKB/TrEMBL
      Q7SYX0
      Related
      ENSXLAP00005011074.1, ENSXLAT00005011248.1
      Conserved Domains (1) summary
      cd02056
      Location:70 → 427
      alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      20153701..20162618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018231859.2 → XP_018087348.1  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A1L8F0C3, A0A974C266
      Conserved Domains (1) summary
      cd19548
      Location:63 → 431
      serpinA_A1AT-like; serpin family A member, alpha-1-antitrypsin and similar serpin proteins in birds and reptiles

    2. XM_041574097.1 → XP_041430031.1  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A1L8F0C3, A0A974C266
      Conserved Domains (1) summary
      cd19548
      Location:63 → 431
      serpinA_A1AT-like; serpin family A member, alpha-1-antitrypsin and similar serpin proteins in birds and reptiles

    3. XM_041574099.1 → XP_041430033.1  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A1L8F0C3, A0A974C266
      Conserved Domains (1) summary
      cd19548
      Location:63 → 431
      serpinA_A1AT-like; serpin family A member, alpha-1-antitrypsin and similar serpin proteins in birds and reptiles

    4. XM_041574098.1 → XP_041430032.1  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A1L8F0C3, A0A974C266
      Conserved Domains (1) summary
      cd19548
      Location:63 → 431
      serpinA_A1AT-like; serpin family A member, alpha-1-antitrypsin and similar serpin proteins in birds and reptiles
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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