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    hrg.L histidine rich glycoprotein L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 446919, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hrg.L
    Official Full Name
    histidine rich glycoprotein L homeolog
    Primary source
    Xenbase:XB-GENE-6254864
    Locus tag
    XELAEV_18027506mg
    See related
    EnsemblRapid:ENSXLAG00005017096 AllianceGenome:Xenbase:XB-GENE-6254864
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    hrgp; fetuinish
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity and heparin binding activity. Predicted to act upstream of or within blood coagulation; fibrinolysis; and negative regulation of endopeptidase activity. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in thrombophilia due to HRG deficiency and thrombosis. Orthologous to human HRG (histidine rich glycoprotein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hrg.L in Genome Data Viewer
    Location:
    chromosome: 5L
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (112789897..112798053, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (102094463..102102664, complement)

    Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 L homeolog Neighboring gene small nucleolar RNA SNORD2 Neighboring gene kininogen 1 L homeolog Neighboring gene fetuin B L homeolog Neighboring gene alpha-2-HS-glycoprotein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fetuin-B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      112789897..112798053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018263610.2 → XP_018119099.1  fetuin-B

      UniProtKB/TrEMBL
      A0A1L8G9Z5, A0A974CWK8, Q66L07
      Related
      ENSXLAP00005050420.1, ENSXLAT00005051561.1
    Nucleotide Protein Strain
    Heading Accession and Version

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