ambp.L alpha-1-microglobulin/bikunin precursor L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ambp.L
Official Full Name: alpha-1-microglobulin/bikunin precursor L homeolog
Primary source: Xenbase:XB-GENE-5747560
Locus tag: XELAEV_18038206mg
See related: EnsemblRapid:ENSXLAG00005018409 AllianceGenome:Xenbase:XB-GENE-5747560
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: a1m; ambp; edc1; hi30; ilil; iatil; itilc
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region. Is expressed in endoderm and liver and biliary system. Human ortholog(s) of this gene implicated in acute kidney failure and adult respiratory distress syndrome. Orthologous to human AMBP (alpha-1-microglobulin/bikunin precursor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 8L

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (1885971..1891269)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (1735413..1740683)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8S	NC_030739.1 (96679287..96681102)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study isolated the Xenopus AMBP cDNA and characterized the peptide structure and developmental regulation of the gene expression. The results showed that Xenopus AMBP gene is repressed through the direct action of thyroid hormone upon liver parenchymal cells at the metamorphic climax stage.
Title: Thyroid hormone-dependent repression of α1-microglobulin/bikunin precursor (AMBP) gene expression during amphibian metamorphosis.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-1-microglobulin/bikunin precursor L homeolog

Names: protein AMBP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087351.2 → NP_001080820.2 alpha-1-microglobulin/bikunin precursor L homeolog precursor

Status: VALIDATED

Source sequence(s)

BC054142

UniProtKB/TrEMBL

A0A974C5J7, Q7SZ46

Related

ENSXLAP00005054401.1, ENSXLAT00005055575.1