sf3b4.S splicing factor 3b subunit 4 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: sf3b4.S
Official Full Name: splicing factor 3b subunit 4 S homeolog
Primary source: Xenbase:XB-GENE-866214
Locus tag: XELAEV_18042748mg
See related: EnsemblRapid:ENSXLAG00005021322 AllianceGenome:Xenbase:XB-GENE-866214
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: spx; sf3b4
Summary: Predicted to enable RNA binding activity. Predicted to be located in nucleus. Is expressed in ectoderm; musculoskeletal system; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in Nager acrofacial dysostosis; cervical cancer; and hepatocellular carcinoma. Orthologous to human SF3B4 (splicing factor 3b subunit 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 8S

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8S	NC_054386.1 (96500068..96509951, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8S	NC_030739.1 (91658679..91668579, complement)

Chromosome 8S - NC_054386.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sf3b4-depleted embryos show reduced expression of the neural crest genes sox10, snail2 and twist at the neural plate border, associated with a broadening of the neural plate. This phenotype can be rescued by injection of wild-type human SF3B4 mRNA but not by mRNAs carrying mutations that cause Nager syndrome.
Title: Sf3b4-depleted Xenopus embryos: A model to study the pathogenesis of craniofacial defects in Nager syndrome.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: splicing factor 3b subunit 4 S homeolog

Names: splicing factor 3b, subunit 4, 49kD; splicing factor 3b, subunit 4, 49kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086631.1 → NP_001080100.1 splicing factor 3b subunit 4 S homeolog

See identical proteins and their annotated locations for NP_001080100.1

Status: PROVISIONAL

Source sequence(s)

BC045264

UniProtKB/TrEMBL

A0A974H6D3, Q7ZX30

Related

ENSXLAP00005062602.1, ENSXLAT00005064056.1

Conserved Domains (2) summary

cd12334
Location:15 → 88

RRM1_SF3B4; RNA recognition motif 1 in splicing factor 3B subunit 4 (SF3B4) and similar proteins

cd12335
Location:99 → 181

RRM2_SF3B4; RNA recognition motif 2 in splicing factor 3B subunit 4 (SF3B4) and similar proteins

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

96500068..96509951 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)