has1.S hyaluronan synthase 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: has1.S
Official Full Name: hyaluronan synthase 1 S homeolog
Primary source: Xenbase:XB-GENE-6256069
Locus tag: XELAEV_18019732mg
See related: AllianceGenome:Xenbase:XB-GENE-6256069
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: dg42; has1; has1.L; xHas-1
Summary: Enables hyaluronan synthase activity. Predicted to act upstream of or within extracellular matrix assembly and extracellular polysaccharide biosynthetic process. Predicted to be located in membrane. Is expressed in dermal system and ectoderm. Orthologous to human HAS1 (hyaluronan synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 3S

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3S	NC_054376.1 (1590220..1594567)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3S	NC_030729.1 (1587447..1591794)

Chromosome 3S - NC_054376.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hyaluronan synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables hyaluronan synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within extracellular matrix assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hyaluronan biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within polysaccharide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hyaluronan synthase 1

Names: HA synthase 1; hyaluronan synthase 1 L homeolog; hyaluronate synthase 1; hyaluronic acid synthase 1; xHAS1

NP_001079696.1

EC 2.4.1.212

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086227.1 → NP_001079696.1 hyaluronan synthase 1

See identical proteins and their annotated locations for NP_001079696.1

Status: PROVISIONAL

Source sequence(s)

M22249

UniProtKB/Swiss-Prot

P13563, Q5D0A1

UniProtKB/TrEMBL

A0A974D6F9

Conserved Domains (2) summary

COG1215
Location:50 → 517

BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]

cl11394
Location:99 → 389

Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold