scp2.L sterol carrier protein 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: scp2.L
Official Full Name: sterol carrier protein 2 L homeolog
Primary source: Xenbase:XB-GENE-975767
Locus tag: XELAEV_18023186mg
See related: EnsemblRapid:ENSXLAG00005035148 AllianceGenome:Xenbase:XB-GENE-975767
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: scp2
Summary: Predicted to enable C-acyltransferase activity; lipid binding activity; and propionyl-CoA C2-trimethyltridecanoyltransferase activity. Predicted to act upstream of or within lipid metabolic process and lipid transport. Predicted to be located in peroxisome. Is expressed in ectoderm; endoderm; urinary system; vestibuloauditory system; and visual system. Orthologous to human SCP2 (sterol carrier protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 4L

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (92334975..92350930)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (87042627..87058583)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of scp2 did not interfere with the patterning of the kidney along its proximo-distal axis, but dramatically decreased the size of the kidney, in particular the proximal tubules.
Title: Sterol carrier protein 2 regulates proximal tubule size in the Xenopus pronephric kidney by modulating lipid rafts.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables acetyl-CoA C-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA C-myristoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables propanoyl-CoA C-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables propionyl-CoA C2-trimethyltridecanoyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sterol carrier protein 2 L homeolog

NP_001088024.1

EC 2.3.1.176

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001094555.1 → NP_001088024.1 sterol carrier protein 2 L homeolog

See identical proteins and their annotated locations for NP_001088024.1

Status: PROVISIONAL

Source sequence(s)

BC082655

UniProtKB/TrEMBL

A0A974HP22, Q640H2

Related

ENSXLAP00005105095.1, ENSXLAT00005107139.1

Conserved Domains (3) summary

PRK08256
Location:6 → 396

PRK08256; lipid-transfer protein; Provisional

cd00826
Location:11 → 395

nondecarbox_cond_enzymes; nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. There are 2 ...

pfam02036
Location:426 → 527

SCP2; SCP-2 sterol transfer family