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    cask.S calcium/calmodulin-dependent serine protein kinase (MAGUK family) S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 446996, updated on 27-Dec-2024

    Summary

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    Official Symbol
    cask.S
    Official Full Name
    calcium/calmodulin-dependent serine protein kinase (MAGUK family) S homeolog
    Primary source
    Xenbase:XB-GENE-1014730
    Locus tag
    XELAEV_18014738mg
    See related
    EnsemblRapid:ENSXLAG00005028508 AllianceGenome:Xenbase:XB-GENE-1014730
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    cask
    Summary
    Predicted to enable ATP binding activity and protein kinase activity. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Orthologous to human CASK (calcium/calmodulin dependent serine protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

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    See cask.S in Genome Data Viewer
    Location:
    chromosome: 2S
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (48688588..48844176)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (45860138..46015968)

    Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene amine oxidase [flavin-containing]-like Neighboring gene uncharacterized LOC108709417 Neighboring gene probable G-protein coupled receptor 82 Neighboring gene nyctalopin S homeolog Neighboring gene DEAD-box helicase 3 X-linked S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC81026

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peripheral plasma membrane protein CASK
    NP_001087107.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001093638.1 → NP_001087107.1  peripheral plasma membrane protein CASK

      See identical proteins and their annotated locations for NP_001087107.1

      Status: PROVISIONAL

      Source sequence(s)
      BC077973
      UniProtKB/TrEMBL
      A0A974DIF8, Q6DCN2
      Related
      ENSXLAP00005085256.1, ENSXLAT00005086919.1
      Conserved Domains (8) summary
      smart00569
      Location:342 → 395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12035
      Location:610 → 671
      SH3_MPP1-like; Src Homology 3 domain of Membrane Protein, Palmitoylated 1 (or MAGUK p55 subfamily member 1)-like proteins
      smart00072
      Location:742 → 908
      GuKc; Guanylate kinase homologues
      smart00220
      Location:12 → 276
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:482 → 562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:732 → 905
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400 → 450
      L27; L27 domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      48688588..48844176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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