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    Ifi208 interferon activated gene 208 [ Mus musculus (house mouse) ]

    Gene ID: 100033459, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ifi208provided by MGI
    Official Full Name
    interferon activated gene 208provided by MGI
    Primary source
    MGI:MGI:2442822
    See related
    Ensembl:ENSMUSG00000066677 AllianceGenome:MGI:2442822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pydc3; Pyr-rv1; NG2creBAC; 9830148g24rik; E430029J22Rik; Tg(Cspg4-cre)1Akik
    Summary
    Predicted to enable double-stranded DNA binding activity and identical protein binding activity. Predicted to be involved in several processes, including regulation of cysteine-type endopeptidase activity; regulation of gene expression; and regulation of innate immune response. Predicted to be located in nucleolus. Predicted to be active in cytosol and nucleoplasm. Orthologous to human IFI16 (interferon gamma inducible protein 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 5.2), mammary gland adult (RPKM 5.0) and 8 other tissues See more
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    Genomic context

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    See Ifi208 in Genome Data Viewer
    Location:
    1 H3; 1 80.57 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173501194..173525959)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173673628..173698393)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interferon activated gene 213 Neighboring gene STARR-positive B cell enhancer ABC_E11699 Neighboring gene STARR-seq mESC enhancer starr_03081 Neighboring gene STARR-positive B cell enhancer ABC_E10060 Neighboring gene STARR-positive B cell enhancer ABC_E5857 Neighboring gene STARR-positive B cell enhancer ABC_E4393 Neighboring gene interferon activated gene 209 Neighboring gene STARR-positive B cell enhancer mm9_chr1:175599072-175599372 Neighboring gene STARR-seq mESC enhancer starr_03083 Neighboring gene pyrin and HIN domain family, member 1 pseudogene Neighboring gene predicted gene 7871

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NG2 cells in white matter but not gray matter proliferate in response to PDGF. Hill RA, et al. J Neurosci, 2013 Sep 4. PMID 24005306, Free PMC Article
    2. Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Armulik A, et al. Dev Cell, 2011 Aug 16. PMID 21839917
    3. Interpericyte tunnelling nanotubes regulate neurovascular coupling. Alarcon-Martinez L, et al. Nature, 2020 Sep. PMID 32788726
    4. Oligodendrocyte lineage cells contribute unique features to Rett syndrome neuropathology. Nguyen MV, et al. J Neurosci, 2013 Nov 27. PMID 24285883, Free PMC Article
    5. In vivo reprogramming of astrocytes to neuroblasts in the adult brain. Niu W, et al. Nat Cell Biol, 2013 Oct. PMID 24056302, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Transgenic (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to interferon-beta IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of AIM2 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interferon-activable protein 208
    Names
    inteferon-activable protein 208
    pyrin domain containing 3
    pyrin domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162938.2 → NP_001156410.1  interferon-activable protein 208 isoform 1

      See identical proteins and their annotated locations for NP_001156410.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC117682
      Consensus CDS
      CCDS48451.1
      UniProtKB/Swiss-Prot
      Q3V3Q4, Q8BLW5
      Related
      ENSMUSP00000083039.4, ENSMUST00000085876.12
      Conserved Domains (2) summary
      cd08305
      Location:14 → 84
      Pyrin; Pyrin: a protein-protein interaction domain
      pfam15695
      Location:505 → 570
      HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113

    2. NM_001379481.1 → NP_001366410.1  interferon-activable protein 208 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117682
      Conserved Domains (1) summary
      cd08305
      Location:14 → 84
      Pyrin; a protein-protein interaction domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      173501194..173525959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238729.3 → XP_011237031.1  interferon-activable protein 208 isoform X1

      Conserved Domains (4) summary
      PRK06347
      Location:88 → 228
      PRK06347; 1,4-beta-N-acetylmuramoylhydrolase
      cd08305
      Location:14 → 84
      Pyrin; a protein-protein interaction domain
      TIGR00601
      Location:176 → 345
      rad23; UV excision repair protein Rad23
      pfam15695
      Location:505 → 572
      HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V3Q4.1 GenPept UniProtKB/Swiss-Prot:Q3V3Q4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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