Marco macrophage receptor with collagenous structure [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Marcoprovided by MGI
Official Full Name: macrophage receptor with collagenous structureprovided by MGI
Primary source: MGI:MGI:1309998
See related: Ensembl:ENSMUSG00000026390 AllianceGenome:MGI:1309998
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly112; Scara2
Summary: Predicted to enable amyloid-beta binding activity and cargo receptor activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Acts upstream of or within apoptotic cell clearance. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of collagen trimer. Predicted to be active in basement membrane and extracellular space. Is expressed in spleen. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human MARCO (macrophage receptor with collagenous structure). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E18 (RPKM 27.1), liver E14 (RPKM 17.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E2.3; 1 52.71 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (120402267..120432753, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (120474538..120505024, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of the scavenger receptor MARCO results in uncontrolled vomocytosis of fungi from macrophages.
Title: Loss of the scavenger receptor MARCO results in uncontrolled vomocytosis of fungi from macrophages.
TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain.
Title: TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain.
MARCO(+) lymphatic endothelial cells sequester arthritogenic alphaviruses to limit viremia and viral dissemination.
Title: MARCO(+) lymphatic endothelial cells sequester arthritogenic alphaviruses to limit viremia and viral dissemination.
Cigarette smoke extract decreased basal and lipopolysaccharide-induced expression of MARCO via degradation of p300.
Title: Cigarette smoke extract decreased basal and lipopolysaccharide-induced expression of MARCO via degradation of p300.
Scavenger receptor MARCO contributes to cellular internalization of exosomes by dynamin-dependent endocytosis and macropinocytosis.
Title: Scavenger receptor MARCO contributes to cellular internalization of exosomes by dynamin-dependent endocytosis and macropinocytosis.
The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
Title: The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
Age-dependent effect between MARCO and TLR4 on PMMA particle phagocytosis by macrophages.
Title: Age-dependent effect between MARCO and TLR4 on PMMA particle phagocytosis by macrophages.
Clearance from the circulation of chikungunya and o'nyong 'nyong virus was independent of natural antibodies or complement factor C3, and instead relied on scavenger receptor SR-A6 (MARCO).
Title: Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses.
the absence of MARCO does not interfere with the efficiency of HSV-1 entry and that the inhibitory effect on viral adsorption by poly(I), a ligand of MARCO, is independent of MARCO.
Title: Entry of Herpes Simplex Virus 1 into Epidermis and Dermal Fibroblasts Is Independent of the Scavenger Receptor MARCO.
presence of MARCO allows rapid Adenovirus (AD) gene expression and strong virus-stimulated innate responses; blockage or lack of MARCO results in strong impairment of these processes;. MARCO is involved in innate Ad recognition and the elevated Ad sensitivity of MARCO-expressing macrophages is due to the expression of this receptor on the cell surface
Title: Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (4) 1 citation

General gene information

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Markers

AI323439 (e-PCR)
- UniSTS:178454

U18424 (e-PCR)
- UniSTS:158845

D1Mit391 (e-PCR), detects polymorphism
- UniSTS:128752

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables cargo receptor activity	IEA Inferred from Electronic Annotation more info
enables cargo receptor activity	ISO Inferred from Sequence Orthology more info
enables extracellular matrix structural constituent conferring tensile strength	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in amyloid-beta clearance	IEA Inferred from Electronic Annotation more info
involved_in amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis, engulfment	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: macrophage receptor MARCO

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010766.3 → NP_034896.1 macrophage receptor MARCO

See identical proteins and their annotated locations for NP_034896.1

Status: VALIDATED

Source sequence(s)

AA185896, BC132338

Consensus CDS

CCDS15234.1

UniProtKB/Swiss-Prot

Q60754

UniProtKB/TrEMBL

A2RT24, Q3TF99

Related

ENSMUSP00000027639.2, ENSMUST00000027639.8

Conserved Domains (3) summary

pfam01391
Location:150 → 207

Collagen; Collagen triple helix repeat (20 copies)

smart00202
Location:423 → 518

SR; Scavenger receptor Cys-rich

pfam00530
Location:428 → 518

SRCR; Scavenger receptor cysteine-rich domain