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    Vnn1 vanin 1 [ Mus musculus (house mouse) ]

    Gene ID: 22361, updated on 3-Dec-2024

    Summary

    Official Symbol
    Vnn1provided by MGI
    Official Full Name
    vanin 1provided by MGI
    Primary source
    MGI:MGI:108395
    See related
    Ensembl:ENSMUSG00000037440 AllianceGenome:MGI:108395
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    V-1
    Summary
    Enables pantetheine hydrolase activity. Involved in several processes, including coenzyme A catabolic process; positive regulation of T cell differentiation in thymus; and positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; facial bone primordium; genitourinary system; nervous system; and respiratory system. Orthologous to human VNN1 (vanin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 31.3), placenta adult (RPKM 24.5) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Vnn1 in Genome Data Viewer
    Location:
    10 A4; 10 11.33 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (23770586..23781242)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (23894688..23905344)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26049 Neighboring gene solute carrier family 18, subfamily B, member 1 Neighboring gene STARR-seq mESC enhancer starr_26051 Neighboring gene STARR-positive B cell enhancer ABC_E8327 Neighboring gene STARR-seq mESC enhancer starr_26053 Neighboring gene vanin 3 Neighboring gene STARR-seq mESC enhancer starr_26055 Neighboring gene STARR-seq mESC enhancer starr_26056 Neighboring gene trace amine-associated receptor 1 Neighboring gene trace amine-associated receptor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GPI anchor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables pantetheine hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pantetheine hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pantetheine hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pantetheine hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    NOT located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pantetheinase
    Names
    pantetheine hydrolase
    vascular non-inflammatory molecule 1
    NP_035834.2
    XP_006512781.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428877.1NP_001415806.1  pantetheinase isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153973
    2. NM_001428878.1NP_001415807.1  pantetheinase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153973
      UniProtKB/TrEMBL
      Q3UEK0
    3. NM_011704.4NP_035834.2  pantetheinase isoform 1 precursor

      See identical proteins and their annotated locations for NP_035834.2

      Status: VALIDATED

      Source sequence(s)
      AC153973
      Consensus CDS
      CCDS35868.1
      UniProtKB/Swiss-Prot
      Q3TJI0, Q8VCT1, Q9DCH8, Q9Z0K8
      Related
      ENSMUSP00000040599.8, ENSMUST00000041416.8
      Conserved Domains (1) summary
      cd07567
      Location:27324
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      23770586..23781242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512718.3XP_006512781.1  pantetheinase isoform X1

      Conserved Domains (1) summary
      cl11424
      Location:1184
      nitrilase; Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes