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    Stox1 storkhead box 1 [ Mus musculus (house mouse) ]

    Gene ID: 216021, updated on 4-Jan-2025

    Summary

    Official Symbol
    Stox1provided by MGI
    Official Full Name
    storkhead box 1provided by MGI
    Primary source
    MGI:MGI:2684909
    See related
    Ensembl:ENSMUSG00000036923 AllianceGenome:MGI:2684909
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm63; 4732470K04Rik
    Summary
    Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including inner ear development; positive regulation of otic vesicle morphogenesis; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in cell cortex and nucleus. Human ortholog(s) of this gene implicated in pre-eclampsia. Orthologous to human STOX1 (storkhead box 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in testis adult (RPKM 3.2), CNS E18 (RPKM 0.8) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Stox1 in Genome Data Viewer
    Location:
    10 B4; 10 32.45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62494822..62561907, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62659043..62726094, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DExD box helicase 50 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62114124-62114233 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62127774-62127957 Neighboring gene predicted gene, 51417 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26891 Neighboring gene STARR-seq mESC enhancer starr_26892 Neighboring gene microRNA 7215 Neighboring gene NHP2 ribonucleoprotein pseudogene Neighboring gene STARR-seq mESC enhancer starr_26893 Neighboring gene cell division cycle and apoptosis regulator 1 Neighboring gene small nucleolar RNA, C/D box 98 Neighboring gene STARR-seq mESC enhancer starr_26894 Neighboring gene tet methylcytosine dioxygenase 1 Neighboring gene STARR-seq mESC enhancer starr_26901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62328128-62328311 Neighboring gene STARR-seq mESC enhancer starr_26907 Neighboring gene predicted gene, 51805

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 30
    Process Evidence Code Pubs
    involved_in cell division  
    involved_in cellular response to nitrosative stress  
    involved_in cellular response to nitrosative stress  
    involved_in inner ear development PubMed 
    involved_in negative regulation of gene expression  
    involved_in negative regulation of gene expression  
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of G2/M transition of mitotic cell cycle  
    involved_in positive regulation of G2/M transition of mitotic cell cycle  
    involved_in positive regulation of cell cycle PubMed 
    involved_in positive regulation of cyclin-dependent protein kinase activity  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of otic vesicle morphogenesis PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of peptidyl-threonine phosphorylation  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in regulation of gene expression  
    involved_in regulation of mitochondrial DNA metabolic process  
    involved_in regulation of mitochondrial DNA metabolic process  
    involved_in regulation of mitochondrial membrane potential  
    involved_in regulation of mitochondrial membrane potential  
    involved_in regulation of mitochondrion organization  
    involved_in regulation of mitochondrion organization  
    involved_in regulation of mitotic cell cycle PubMed 
    involved_in regulation of response to oxidative stress  
    involved_in regulation of response to oxidative stress  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    Items 1 - 25 of 30
    Component Evidence Code Pubs
    located_in cell cortex PubMed 
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in fibrillar center  
    located_in fibrillar center  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033260.2NP_001028432.1  storkhead-box protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001028432.1

      Status: VALIDATED

      Source sequence(s)
      AI842662, AK133671, BC137978
      Consensus CDS
      CCDS48580.1
      UniProtKB/Swiss-Prot
      B2RQL2, Q3UZS9
      Related
      ENSMUSP00000114652.2, ENSMUST00000133371.8
      Conserved Domains (1) summary
      pfam10264
      Location:109185
      Stork_head; Winged helix Storkhead-box1 domain
    2. NM_001364705.1NP_001351634.1  storkhead-box protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI842662, AK133671, BC137978, BE988760
      Conserved Domains (1) summary
      pfam10264
      Location:109185
      Stork_head; Winged helix Storkhead-box1 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      62494822..62561907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513474.2XP_006513537.1  storkhead-box protein 1 isoform X1

      Conserved Domains (1) summary
      pfam10264
      Location:278
      Stork_head; Winged helix Storkhead-box1 domain
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