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    Frmpd2 FERM and PDZ domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 268729, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Frmpd2provided by MGI
    Official Full Name
    FERM and PDZ domain containing 2provided by MGI
    Primary source
    MGI:MGI:2685472
    See related
    Ensembl:ENSMUSG00000108841 AllianceGenome:MGI:2685472
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm626; Gm1582
    Summary
    Predicted to enable 1-phosphatidylinositol binding activity. Predicted to be involved in bicellular tight junction assembly. Predicted to be located in basolateral plasma membrane and bicellular tight junction. Is expressed in central nervous system; ganglia; and retina. Orthologous to human FRMPD2 (FERM and PDZ domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Frmpd2 in Genome Data Viewer
    Location:
    14 B; 14 20.46 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33193475..33297226)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (33483501..33575269)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 22 Neighboring gene predicted gene, 41130 Neighboring gene STARR-seq mESC enhancer starr_36351 Neighboring gene mitogen-activated protein kinase 8 Neighboring gene STARR-seq mESC enhancer starr_36353 Neighboring gene protein tyrosine phosphatase, non-receptor type 20 Neighboring gene predicted gene, 26228

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The second PDZ domain of scaffold protein Frmpd2 binds to GluN2A of NMDA receptors. Lu X, et al. Biochem Biophys Res Commun, 2019 Aug 13. PMID 31196628
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical part of cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FERM and PDZ domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      33193475..33297226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316244.2 → XP_017171733.1  FERM and PDZ domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      A0A140LI67
      Conserved Domains (6) summary
      smart00228
      Location:930 → 1018
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      smart00295
      Location:334 → 538
      B41; Band 4.1 homologues
      cd00992
      Location:775 → 859
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl17171
      Location:534 → 635
      PH-like; Pleckstrin homology-like domain
      cl21453
      Location:6 → 188
      PKc_like; Protein Kinases, catalytic domain
      cl28922
      Location:329 → 422
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_036158980.1 → XP_036014873.1  FERM and PDZ domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A0A140LI67
      Related
      ENSMUSP00000146693.2, ENSMUST00000208577.2
      Conserved Domains (6) summary
      smart00228
      Location:930 → 1018
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      smart00295
      Location:334 → 538
      B41; Band 4.1 homologues
      cd00992
      Location:775 → 859
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl17171
      Location:534 → 635
      PH-like; Pleckstrin homology-like domain
      cl21453
      Location:6 → 188
      PKc_like; Protein Kinases, catalytic domain
      cl28922
      Location:329 → 422
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. XM_036158982.1 → XP_036014875.1  FERM and PDZ domain-containing protein 2 isoform X3

      UniProtKB/Swiss-Prot
      A0A140LI67
      Conserved Domains (6) summary
      smart00228
      Location:912 → 1000
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      smart00295
      Location:334 → 538
      B41; Band 4.1 homologues
      cd00992
      Location:757 → 841
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl17171
      Location:534 → 635
      PH-like; Pleckstrin homology-like domain
      cl21453
      Location:6 → 188
      PKc_like; Protein Kinases, catalytic domain
      cl28922
      Location:329 → 422
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A140LI67.1 GenPept UniProtKB/Swiss-Prot:A0A140LI67

    Gene LinkOut

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    Chemical Information
    Molecular Biology Databases
    Research Materials