Bcl6 B cell leukemia/lymphoma 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcl6provided by MGI
Official Full Name: B cell leukemia/lymphoma 6provided by MGI
Primary source: MGI:MGI:107187
See related: Ensembl:ENSMUSG00000022508 AllianceGenome:MGI:107187
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bcl5
Summary: Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of lymphocyte activation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Human ortholog(s) of this gene implicated in B-cell lymphoma and diffuse large B-cell lymphoma. Orthologous to human BCL6 (BCL6 transcription repressor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in thymus adult (RPKM 22.9), subcutaneous fat pad adult (RPKM 15.7) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B1; 16 15.26 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (23780058..23807602, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (23965050..23988866, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation.
Title: Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation.
The aged microenvironment impairs BCL6 and CD40L induction in CD4[+] T follicular helper cell differentiation.
Title: The aged microenvironment impairs BCL6 and CD40L induction in CD4(+) T follicular helper cell differentiation.
Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis.
Title: Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis.
Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses.
Title: Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses.
Epidermal loss of Bcl6 exacerbates MC903-induced atopic dermatitis-like skin inflammation.
Title: Epidermal loss of Bcl6 exacerbates MC903-induced atopic dermatitis-like skin inflammation.
IRF4 induces M1 macrophage polarization and aggravates ulcerative colitis progression by the Bcl6-dependent STAT3 pathway.
Title: IRF4 induces M1 macrophage polarization and aggravates ulcerative colitis progression by the Bcl6-dependent STAT3 pathway.
BCL6 attenuates hyperoxia-induced lung injury by inhibiting NLRP3-mediated inflammation in fetal mouse.
Title: BCL6 attenuates hyperoxia-induced lung injury by inhibiting NLRP3-mediated inflammation in fetal mouse.
Inhibition of Bcl-6 Expression Ameliorates Asthmatic Characteristics in Mice.
Title: Inhibition of Bcl-6 Expression Ameliorates Asthmatic Characteristics in Mice.
BCL6 is required for the thymic development of TCRalphabeta[+]CD8alphaalpha[+] intraepithelial lymphocyte lineage.
Title: BCL6 is required for the thymic development of TCRαβ(+)CD8αα(+) intraepithelial lymphocyte lineage.
Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress.
Title: Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress.

Submit: New GeneRIF Correction See all GeneRIFs (170)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (16) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U41465 (e-PCR)
- UniSTS:125745

Bcl6 (e-PCR), detects polymorphism
- UniSTS:141170

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intronic transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Rho protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T-helper 2 cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germinal center formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of isotype switching to IgE isotypes	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of isotype switching to IgE isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mast cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mononuclear cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T-helper 2 cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cellular senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of isotype switching to IgE isotypes	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of isotype switching to IgE isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mast cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mononuclear cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of plasma cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of type 2 immune response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of plasma cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of regulatory T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of pyramidal neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of memory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in type 2 immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within type 2 immune response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in paraspeckles	IEA Inferred from Electronic Annotation more info
located_in paraspeckles	ISO Inferred from Sequence Orthology more info
located_in replication fork	IEA Inferred from Electronic Annotation more info
colocalizes_with replication fork	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: B-cell lymphoma 6 protein homolog

Names: B-cell leukemia/lymphoma 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001348026.2 → NP_001334955.1 B-cell lymphoma 6 protein homolog isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC158397

Consensus CDS

CCDS28082.1

UniProtKB/Swiss-Prot

P41183, Q61065

UniProtKB/TrEMBL

Q544F9, Q8CB25

Conserved Domains (4) summary

PHA03247
Location:179 → 429

PHA03247; large tegument protein UL36; Provisional

sd00017
Location:577 → 597

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18331
Location:8 → 125

BTB_POZ_ZBTB27_BCL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)

pfam13465
Location:589 → 614

zf-H2C2_2; Zinc-finger double domain
NM_001416608.1 → NP_001403537.1 B-cell lymphoma 6 protein homolog isoform 1

Status: VALIDATED

Source sequence(s)

AC158397

UniProtKB/Swiss-Prot

P41183, Q61065

UniProtKB/TrEMBL

Q544F9, Q8CB25
NM_001416610.1 → NP_001403539.1 B-cell lymphoma 6 protein homolog isoform 2

Status: VALIDATED

Source sequence(s)

AC158397
NM_009744.5 → NP_033874.1 B-cell lymphoma 6 protein homolog isoform 1

See identical proteins and their annotated locations for NP_033874.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC158397

Consensus CDS

CCDS28082.1

UniProtKB/Swiss-Prot

P41183, Q61065

UniProtKB/TrEMBL

Q544F9, Q8CB25

Related

ENSMUSP00000023151.6, ENSMUST00000023151.6

Conserved Domains (4) summary

PHA03247
Location:179 → 429

PHA03247; large tegument protein UL36; Provisional

sd00017
Location:577 → 597

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18331
Location:8 → 125

BTB_POZ_ZBTB27_BCL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)

pfam13465
Location:589 → 614

zf-H2C2_2; Zinc-finger double domain