Nanp N-acetylneuraminic acid phosphatase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nanpprovided by MGI
Official Full Name: N-acetylneuraminic acid phosphataseprovided by MGI
Primary source: MGI:MGI:1914561
See related: Ensembl:ENSMUSG00000053916 AllianceGenome:MGI:1914561
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hdhd4; 1600031M04Rik
Summary: Predicted to enable N-acylneuraminate-9-phosphatase activity. Predicted to be involved in N-acetylneuraminate biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; liver; submandibular gland primordium; and telencephalon ventricular layer. Orthologous to human NANP (N-acetylneuraminic acid phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E14 (RPKM 18.1), liver E14.5 (RPKM 15.0) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G3; 2 74.83 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (150871605..150881299, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (151029685..151039379, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acylneuraminate-9-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acylneuraminate-9-phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables N-acylneuraminate-9-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in CMP-N-acetylneuraminate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in CMP-N-acetylneuraminate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in N-acetylglucosamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in N-acetylneuraminate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acetylneuraminate biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in N-acetylneuraminate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-acetylneuraminate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: N-acylneuraminate-9-phosphatase

Names: haloacid dehalogenase-like hydrolase domain containing 4; haloacid dehalogenase-like hydrolase domain-containing protein 4; neu5Ac-9-Pase

NP_080362.1

EC 3.1.3.29

XP_006500131.1

EC 3.1.3.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026086.2 → NP_080362.1 N-acylneuraminate-9-phosphatase

See identical proteins and their annotated locations for NP_080362.1

Status: VALIDATED

Source sequence(s)

AL808125, BC083086

Consensus CDS

CCDS16864.1

UniProtKB/Swiss-Prot

Q9CPT3

Related

ENSMUSP00000063895.5, ENSMUST00000066640.5

Conserved Domains (2) summary

TIGR02253
Location:6 → 234

CTE7; HAD superfamily (subfamily IA) hydrolase, TIGR02253

cl21460
Location:114 → 239

HAD_like; Haloacid Dehalogenase-like Hydrolases