Hspb8 heat shock protein 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hspb8provided by MGI
Official Full Name: heat shock protein 8provided by MGI
Primary source: MGI:MGI:2135756
See related: Ensembl:ENSMUSG00000041548 AllianceGenome:MGI:2135756
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H11; H11K; Cryac; E2IG1; HSP22; D5Ucla4; HSP20-like
Summary: Predicted to enable protein homodimerization activity. Predicted to be involved in cellular response to unfolded protein and positive regulation of aggrephagy. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein folding chaperone complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study autosomal dominant distal hereditary motor neuronopathy 2. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2L and autosomal dominant distal hereditary motor neuronopathy 2. Orthologous to human HSPB8 (heat shock protein family B (small) member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 200.3), liver adult (RPKM 87.3) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.41 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (116546550..116560923, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (116408491..116422864, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSPB8 up-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy.
Title: HSPB8 up-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy.
HSPB8-Mediated Actin Filament Reorganization by Promoting Autophagic Flux Confers Resilience to Blood-Brain Barrier (BBB) Injury in an In Vitro Model of Ischemic Stroke.
Title: HSPB8-Mediated Actin Filament Reorganization by Promoting Autophagic Flux Confers Resilience to Blood-Brain Barrier (BBB) Injury in an In Vitro Model of Ischemic Stroke.
HSPB8 Overexpression Ameliorates Cognitive Impairment in Diabetic Mice via Inhibiting NLRP3 Inflammation Activation.
Title: HSPB8 Overexpression Ameliorates Cognitive Impairment in Diabetic Mice via Inhibiting NLRP3 Inflammation Activation.
Small Heat Shock Protein 22 Improves Cognition and Learning in the Tauopathic Brain.
Title: Small Heat Shock Protein 22 Improves Cognition and Learning in the Tauopathic Brain.
this study shows that Hsp22 overexpression induces myocardial hypertrophy, senescence and reduced life span through enhanced oxidative stress
Title: Hsp22 overexpression induces myocardial hypertrophy, senescence and reduced life span through enhanced oxidative stress.
HSP22 reduces elevated lipid peroxidation levels and apoptosis during lung ischemia-reperfusion injury in mice.
Title: The protective effects of heat shock protein 22 in lung ischemia-reperfusion injury mice.
Results suggest that toxic gain-of-function of mutant Hspb8 aggregates is a major contributor to the peripheral neuropathy and the myopathy. In addition, mutant Hspb8 induces impairments in autophagy that may aggravate the phenotype.
Title: A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8.
These results strongly suggest that HSP22 interacts with mTOR and regulates TNF-alpha-induced IL-6 synthesis in osteoblasts.
Title: Association of HSP22 with mTOR in osteoblasts: regulation of TNF-α-stimulated IL-6 synthesis.
HSP22 functions as a negative regulator in the TGF-beta-stimulated migration of osteoblasts.
Title: Heat shock protein 22 (HSPB8) limits TGF-β-stimulated migration of osteoblasts.
Results revealed that the apoptosis-suppressing effect of heat shock protein B8 was mediated by the PI3K/Akt pathway in an in vitro model of ischemia.
Title: HspB8 mediates neuroprotection against OGD/R in N2A cells through the phosphoinositide 3-kinase/Akt pathway.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235285

RH136226 (e-PCR)
- UniSTS:210220

AW413033 (e-PCR)
- UniSTS:179247

AW743423 (e-PCR)
- UniSTS:207858

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to unfolded protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to unfolded protein	IEA Inferred from Electronic Annotation more info
involved_in cellular response to unfolded protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of aggrephagy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of aggrephagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein folding chaperone complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein folding chaperone complex	IEA Inferred from Electronic Annotation more info
part_of protein folding chaperone complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heat shock protein beta-8

Names: alpha-crystallin C chain; crystallin, alpha C; heat shock 27kDa protein 8; heat shock protein 20-like protein; small stress protein-like protein HSP22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030704.3 → NP_109629.1 heat shock protein beta-8

See identical proteins and their annotated locations for NP_109629.1

Status: VALIDATED

Source sequence(s)

AI326838, AK005052

Consensus CDS

CCDS19600.1

UniProtKB/Swiss-Prot

Q9JK92

Related

ENSMUSP00000037007.5, ENSMUST00000036991.5

Conserved Domains (1) summary

cd06480
Location:80 → 170

ACD_HspB8_like; Alpha-crystallin domain (ACD) found in mammalian 21.6 KDa small heat shock protein (sHsp) HspB8, also denoted as Hsp22 in humans, and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and ...