Trappc14 trafficking protein particle complex 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trappc14provided by MGI
Official Full Name: trafficking protein particle complex 14provided by MGI
Primary source: MGI:MGI:2385896
See related: Ensembl:ENSMUSG00000036948 AllianceGenome:MGI:2385896
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Map11
Summary: Predicted to enable alpha-tubulin binding activity. Predicted to be involved in cilium assembly and regulation of cell population proliferation. Predicted to be located in several cellular components, including microtubule cytoskeleton; midbody; and plasma membrane. Predicted to be part of TRAPPII protein complex. Is expressed in liver; nervous system; neural retina; and thymus primordium. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human TRAPPC14 (trafficking protein particle complex subunit 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 50.1), spleen adult (RPKM 46.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 77.0 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (138257920..138262323, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (138259658..138264061, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables alpha-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of TRAPPII protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TRAPPII protein complex	ISO Inferred from Sequence Orthology more info
part_of TRAPPII protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: trafficking protein particle complex subunit 14

Names: MAP11 short transcript; microtubule associated protein 11; uncharacterized protein C7orf43 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153161.3 → NP_694801.2 trafficking protein particle complex subunit 14

Status: VALIDATED

Source sequence(s)

AC159257, AK138960, AW824316

Consensus CDS

CCDS39343.2

UniProtKB/Swiss-Prot

E9Q2V5, Q3UTZ3, Q8JZV2

Related

ENSMUSP00000046898.8, ENSMUST00000048421.14

Conserved Domains (1) summary

pfam15806
Location:139 → 579

DUF4707; Domain of unknown function (DUF4707)