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    Plxna4 plexin A4 [ Mus musculus (house mouse) ]

    Gene ID: 243743, updated on 4-Jan-2025

    Summary

    Official Symbol
    Plxna4provided by MGI
    Official Full Name
    plexin A4provided by MGI
    Primary source
    MGI:MGI:2179061
    See related
    Ensembl:ENSMUSG00000029765 AllianceGenome:MGI:2179061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Plxa4; mKIAA1550; 9330117B14
    Summary
    Enables semaphorin receptor activity. Involved in several processes, including maintenance of synapse structure; nervous system development; and semaphorin-plexin signaling pathway. Acts upstream of or within nervous system development; regulation of axon extension involved in axon guidance; and regulation of negative chemotaxis. Is active in cerebellar climbing fiber to Purkinje cell synapse. Is expressed in several structures, including alimentary system; nervous system; and sensory organ. Orthologous to human PLXNA4 (plexin A4). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in CNS E18 (RPKM 7.4), CNS E14 (RPKM 6.4) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Plxna4 in Genome Data Viewer
    Location:
    6 A3.3; 6 12.9 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (32121478..32565127, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (32144543..32588192, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700012A03 gene Neighboring gene predicted gene 13850 Neighboring gene plexin A4, opposite strand 1 Neighboring gene predicted gene, 46956 Neighboring gene predicted gene, 32007

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Interactions

    General gene information

    Clone Names

    • KIAA1550

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables semaphorin receptor activity  
    enables semaphorin receptor activity PubMed 
    Items 1 - 25 of 30
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior commissure morphogenesis PubMed 
    involved_in axon guidance  
    acts_upstream_of_or_within axon guidance PubMed 
    involved_in branchiomotor neuron axon guidance PubMed 
    acts_upstream_of_or_within chemorepulsion of branchiomotor axon PubMed 
    acts_upstream_of_or_within cranial nerve morphogenesis PubMed 
    involved_in embryonic heart tube development PubMed 
    involved_in embryonic heart tube development PubMed 
    acts_upstream_of_or_within facial nerve morphogenesis PubMed 
    involved_in facial nerve structural organization PubMed 
    acts_upstream_of_or_within glossopharyngeal nerve morphogenesis PubMed 
    involved_in maintenance of synapse structure PubMed 
    involved_in maintenance of synapse structure PubMed 
    involved_in motor neuron axon guidance PubMed 
    acts_upstream_of_or_within nervous system development PubMed 
    acts_upstream_of_or_within neuron projection morphogenesis PubMed 
    acts_upstream_of_or_within postganglionic parasympathetic fiber development PubMed 
    acts_upstream_of_or_within regulation of axon extension involved in axon guidance PubMed 
    involved_in regulation of cell migration  
    acts_upstream_of_or_within regulation of negative chemotaxis PubMed 
    involved_in semaphorin-plexin signaling pathway  
    acts_upstream_of_or_within semaphorin-plexin signaling pathway PubMed 
    acts_upstream_of_or_within semaphorin-plexin signaling pathway PubMed 
    involved_in semaphorin-plexin signaling pathway PubMed 
    acts_upstream_of_or_within sympathetic nervous system development PubMed 
    involved_in sympathetic neuron axon guidance PubMed 
    involved_in synapse assembly  
    acts_upstream_of_or_within trigeminal nerve morphogenesis PubMed 
    involved_in trigeminal nerve structural organization PubMed 
    acts_upstream_of_or_within vagus nerve morphogenesis PubMed 
    Items 1 - 25 of 30
    Component Evidence Code Pubs
    is_active_in cerebellar climbing fiber to Purkinje cell synapse PubMed 
    is_active_in cerebellar climbing fiber to Purkinje cell synapse PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    part_of semaphorin receptor complex  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175750.3NP_786926.2  plexin-A4 precursor

      See identical proteins and their annotated locations for NP_786926.2

      Status: VALIDATED

      Source sequence(s)
      AB073228, AC153629, AC158678, BF456700
      Consensus CDS
      CCDS19985.2
      UniProtKB/Swiss-Prot
      E9QN64, Q5DTW8, Q80UG2, Q8BKK9
      UniProtKB/TrEMBL
      B9EJ29
      Related
      ENSMUSP00000110748.3, ENSMUST00000115096.4
      Conserved Domains (8) summary
      cd11274
      Location:38510
      Sema_plexin_A4; The Sema domain, a protein interacting module, of Plexin A4
      smart00423
      Location:509547
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd00603
      Location:11411221
      IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
      cd01179
      Location:9541037
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:857952
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:10391139
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:803855
      PSI; Plexin repeat
      pfam08337
      Location:13101863
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      32121478..32565127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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