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    Actmap actin maturation protease [ Mus musculus (house mouse) ]

    Gene ID: 414069, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Actmapprovided by MGI
    Official Full Name
    actin maturation proteaseprovided by MGI
    Primary source
    MGI:MGI:3041247
    See related
    Ensembl:ENSMUSG00000078786 AllianceGenome:MGI:3041247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables initiator methionyl aminopeptidase activity. Involved in protein processing. Predicted to be located in cytoplasm. Orthologous to human ACTMAP (actin maturation protease). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.9), adrenal adult (RPKM 5.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Actmap in Genome Data Viewer
    Location:
    7 A3; 7 15.84 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26894973..26909611)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27195781..27210184)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancers ABC_E1725 and ABC_E288 Neighboring gene RAB4B, member RAS oncogene family Neighboring gene microRNA 3101 Neighboring gene MIA SH3 domain containing Neighboring gene STARR-positive B cell enhancer ABC_E3707 Neighboring gene small nuclear ribonucleoprotein polypeptide A Neighboring gene microRNA 1191 Neighboring gene inositol 1,4,5-trisphosphate 3-kinase C Neighboring gene STARR-positive B cell enhancer ABC_E2229 Neighboring gene coenzyme Q8B Neighboring gene STARR-positive B cell enhancer ABC_E4906 Neighboring gene numb-like Neighboring gene ribosomal protein L14 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Actin maturation requires the ACTMAP/C19orf54 protease. Haahr P, et al. Science, 2022 Sep 30. PMID 36173861
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables initiator methionyl aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables initiator methionyl aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables initiator methionyl aminopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    actin maturation protease
    Names
    UPF0692 protein C19orf54 homolog
    actin aminopeptidase ACTMAP
    NP_001230817.1
    NP_001277440.1
    NP_001277442.1
    XP_017177823.1
    XP_030098596.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243888.1 → NP_001230817.1  actin maturation protease isoform 1

      See identical proteins and their annotated locations for NP_001230817.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC157561
      Consensus CDS
      CCDS57529.1
      UniProtKB/Swiss-Prot
      D3Z7G4, J3QPC3
      Related
      ENSMUSP00000137189.2, ENSMUST00000179391.8

    2. NM_001290511.1 → NP_001277440.1  actin maturation protease isoform 2

      See identical proteins and their annotated locations for NP_001277440.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC157561
      UniProtKB/TrEMBL
      F6XBP4
      Related
      ENSMUSP00000123290.2, ENSMUST00000155931.2

    3. NM_001290513.1 → NP_001277442.1  actin maturation protease isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC157561
      Consensus CDS
      CCDS71921.1
      UniProtKB/TrEMBL
      D3Z7G4
      Related
      ENSMUSP00000104016.2, ENSMUST00000108379.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      26894973..26909611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242736.2 → XP_030098596.1  actin maturation protease isoform X1

    2. XM_017322334.3 → XP_017177823.1  actin maturation protease isoform X1

    RNA

    1. XR_881742.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    J3QPC3.1 GenPept UniProtKB/Swiss-Prot:J3QPC3

    Gene LinkOut

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    Research Materials