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    Coa4 cytochrome c oxidase assembly factor 4 [ Mus musculus (house mouse) ]

    Gene ID: 68185, updated on 9-Dec-2024

    Summary

    Official Symbol
    Coa4provided by MGI
    Official Full Name
    cytochrome c oxidase assembly factor 4provided by MGI
    Primary source
    MGI:MGI:1915435
    See related
    Ensembl:ENSMUSG00000044881 AllianceGenome:MGI:1915435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E2ig2; Chchd8; 5330414O08Rik
    Summary
    Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial intermembrane space. Orthologous to human COA4 (cytochrome c oxidase assembly factor 4 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 8.7), placenta adult (RPKM 8.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Coa4 in Genome Data Viewer
    Location:
    7 E2; 7 54.36 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100186307..100189579)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100537100..100540372)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B13 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:107685672-107685781 Neighboring gene predicted gene, 39058 Neighboring gene predicted gene, 39059 Neighboring gene mitochondrial ribosomal protein L48 Neighboring gene cytochrome c oxidase assembly protein 20B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    General gene information

    Markers

    Clone Names

    • MGC106079

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cytochrome c oxidase assembly factor 4 homolog, mitochondrial
    Names
    coiled-coil-helix-coiled-coil-helix domain containing 8
    coiled-coil-helix-coiled-coil-helix domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183270.2NP_899093.1  cytochrome c oxidase assembly factor 4 homolog, mitochondrial

      See identical proteins and their annotated locations for NP_899093.1

      Status: VALIDATED

      Source sequence(s)
      AK161506
      Consensus CDS
      CCDS40037.1
      UniProtKB/Swiss-Prot
      Q4VA04, Q8BT51
      Related
      ENSMUSP00000053727.4, ENSMUST00000054310.4
      Conserved Domains (1) summary
      pfam06747
      Location:3467
      CHCH; CHCH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      100186307..100189579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508152.2XP_006508215.1  cytochrome c oxidase assembly factor 4 homolog, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006508215.1

      UniProtKB/Swiss-Prot
      Q4VA04, Q8BT51
      Related
      ENSMUSP00000114098.2, ENSMUST00000120454.3
      Conserved Domains (1) summary
      pfam06747
      Location:3467
      CHCH; CHCH domain