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    Bnc1 basonuclin zinc finger protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 12173, updated on 27-Nov-2024

    Summary

    Official Symbol
    Bnc1provided by MGI
    Official Full Name
    basonuclin zinc finger protein 1provided by MGI
    Primary source
    MGI:MGI:1097164
    See related
    Ensembl:ENSMUSG00000025105 AllianceGenome:MGI:1097164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bnc
    Summary
    Predicted to enable DNA-binding transcription activator activity and rDNA binding activity. Acts upstream of or within several processes, including positive regulation of epithelial cell proliferation; regulation of DNA-templated transcription; and wound healing. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; branchial arch; gonad; outer layer of bladder; and skin. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 16. Orthologous to human BNC1 (basonuclin zinc finger protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary adult (RPKM 1.4), placenta adult (RPKM 1.2) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Bnc1 in Genome Data Viewer
    Location:
    7 D3; 7 45.71 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (81616401..81642047, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (81966657..81992299, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32695 Neighboring gene predicted gene, 51491 Neighboring gene STARR-seq mESC enhancer starr_19372 Neighboring gene transmembrane 6 superfamily member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:89025770-89025983 Neighboring gene STARR-seq mESC enhancer starr_19373 Neighboring gene HDGF like 3 Neighboring gene STARR-seq mESC enhancer starr_19374 Neighboring gene STARR-seq mESC enhancer starr_19375 Neighboring gene STARR-seq mESC enhancer starr_19377 Neighboring gene predicted gene, 46013 Neighboring gene STARR-seq mESC enhancer starr_19378 Neighboring gene predicted gene, 20744

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables rDNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger protein basonuclin-1
    Names
    basonuclin 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007562.2NP_031588.2  zinc finger protein basonuclin-1

      See identical proteins and their annotated locations for NP_031588.2

      Status: VALIDATED

      Source sequence(s)
      AC161216, AK051041, AK087567, BY146829
      Consensus CDS
      CCDS52285.1
      UniProtKB/Swiss-Prot
      O35914, O54886
      UniProtKB/TrEMBL
      F8VPY0
      Related
      ENSMUSP00000026096.8, ENSMUST00000026096.10
      Conserved Domains (1) summary
      sd00017
      Location:356377
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      81616401..81642047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250781.4XP_011249083.1  zinc finger protein basonuclin-1 isoform X1

      UniProtKB/Swiss-Prot
      O35914, O54886
      Conserved Domains (2) summary
      sd00017
      Location:354375
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:924945
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_011250782.3XP_011249084.1  zinc finger protein basonuclin-1 isoform X2

      UniProtKB/Swiss-Prot
      O35914, O54886
      Conserved Domains (2) summary
      sd00017
      Location:350371
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam16014
      Location:432574
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus