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    Kcnip1 Kv channel-interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 70357, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kcnip1provided by MGI
    Official Full Name
    Kv channel-interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1917607
    See related
    Ensembl:ENSMUSG00000053519 AllianceGenome:MGI:1917607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KCHIP1; Kchip1.2
    Summary
    Predicted to enable calcium ion binding activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in positive regulation of action potential; regulation of potassium ion transmembrane transport; and regulation of signal transduction. Part of voltage-gated potassium channel complex. Is expressed in several structures, including brain; ganglia; intestine smooth muscle circular layer; spinal cord; and testis. Orthologous to human KCNIP1 (potassium voltage-gated channel interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 12.1), CNS E18 (RPKM 11.7) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcnip1 in Genome Data Viewer
    Location:
    11 A4; 11 19.21 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (33579339..33943854, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (33629339..33993348, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29136 Neighboring gene RIKEN cDNA D130052B06 gene Neighboring gene gamma-aminobutyric acid type A receptor subunit pi Neighboring gene predicted gene 12119 Neighboring gene STARR-seq mESC enhancer starr_29137 Neighboring gene STARR-seq mESC enhancer starr_29138 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:33819926-33820148 Neighboring gene STARR-positive B cell enhancer ABC_E8390 Neighboring gene predicted gene, 39677 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:33838922-33839284 Neighboring gene RIKEN cDNA 4930469K13 gene Neighboring gene predicted gene, 36395 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:33908807-33908990 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 1 Neighboring gene predicted gene, 51857 Neighboring gene predicted gene, 53680 Neighboring gene STARR-seq mESC enhancer starr_29140 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:33964098-33964329 Neighboring gene lymphocyte cytosolic protein 2 Neighboring gene predicted gene 12121

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Roles of KChIP1 in the regulation of GABA-mediated transmission and behavioral anxiety. Xia K, et al. Mol Brain, 2010 Aug 2. PMID 20678225, Free PMC Article
    2. KChIP1: a potential modulator to GABAergic system. Xiong H, et al. Acta Biochim Biophys Sin (Shanghai), 2009 Apr. PMID 19352544
    3. Differential modulation of Kv4 kinetics by KCHIP1 splice variants. Van Hoorick D, et al. Mol Cell Neurosci, 2003 Oct. PMID 14572458
    4. The aromatic cluster in KCHIP1b affects Kv4 inactivation gating. Van Hoorick D, et al. J Physiol, 2007 Sep 15. PMID 17640927, Free PMC Article
    5. Differential distribution of KChIPs mRNAs in adult mouse brain. Xiong H, et al. Brain Res Mol Brain Res, 2004 Sep 28. PMID 15363885

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KChIP1 is a synaptic protein that regulates behavioral anxiety by modulating inhibitory synaptic transmission.
      Title: Roles of KChIP1 in the regulation of GABA-mediated transmission and behavioral anxiety.
    2. KChIP1 deletion showed increased susceptibility to anti-GABAergic convulsive drug pentylenetetrazole-induced seizure, indicating that KChIP1 might play pivotal roles in the GABAergic inhibitory system.
      Title: KChIP1: a potential modulator to GABAergic system.
    3. aromatic cluster in exon1b modulates the transitions towards and from the closed inactivated states and the steady state distribution over the respective states
      Title: The aromatic cluster in KCHIP1b affects Kv4 inactivation gating.
    4. KChIP1 was expressed in a subpopulation of neurons widely distributed in brain and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei.
      Title: Differential distribution of KChIPs mRNAs in adult mouse brain.
    5. Differential expression of KCh1P1 splice variants can shape the function of Kv4.2 channels involved in protection against back propagating action potentials in dendritic spines.
      Title: Differential modulation of Kv4 kinetics by KCHIP1 splice variants.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • 2900046L02Rik, 3202002F18Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in membrane repolarization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in muscle contraction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion export across plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of heart contraction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Kv4.3-KChIP1 channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A-type potassium channel modulatory protein KCNIP1; Kv channel-interacting protein 1
    Names
    A-type potassium channel modulatory protein 1
    A-type potassium channel modulatory protein 1.2
    potassium channel-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190885.3 → NP_001177814.1  A-type potassium channel modulatory protein KCNIP1 isoform A

      See identical proteins and their annotated locations for NP_001177814.1

      Status: VALIDATED

      Source sequence(s)
      AL669814, AL731867
      Consensus CDS
      CCDS56766.1
      UniProtKB/Swiss-Prot
      Q5SSA3, Q6DTJ1, Q8BGJ4, Q8C4K4, Q8CGL1, Q8K1U1, Q8K3M2, Q9JJ57
      UniProtKB/TrEMBL
      Q3YAB4
      Related
      ENSMUSP00000104964.3, ENSMUST00000109340.9
      Conserved Domains (1) summary
      COG5126
      Location:50 → 216
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. NM_001190886.2 → NP_001177815.1  A-type potassium channel modulatory protein KCNIP1 isoform C

      See identical proteins and their annotated locations for NP_001177815.1

      Status: VALIDATED

      Source sequence(s)
      AL669814, AL731867
      Consensus CDS
      CCDS88143.1
      UniProtKB/TrEMBL
      A0A571BET8, Q3YAB5
      Related
      ENSMUSP00000158966.2, ENSMUST00000238903.2
      Conserved Domains (2) summary
      COG5126
      Location:48 → 214
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:135 → 206
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. NM_001290690.3 → NP_001277619.1  A-type potassium channel modulatory protein KCNIP1 isoform D

      See identical proteins and their annotated locations for NP_001277619.1

      Status: VALIDATED

      Source sequence(s)
      AL669814, AL731867
      Consensus CDS
      CCDS70160.1
      UniProtKB/TrEMBL
      Q3YAB4
      Related
      ENSMUSP00000098919.3, ENSMUST00000101368.9
      Conserved Domains (1) summary
      COG5126
      Location:11 → 177
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    4. NM_001363115.2 → NP_001350044.1  A-type potassium channel modulatory protein KCNIP1 isoform E

      Status: VALIDATED

      Source sequence(s)
      AL662902, AL669814
      UniProtKB/TrEMBL
      A0A571BET8
      Related
      ENSMUSP00000158813.2, ENSMUST00000238436.2
      Conserved Domains (1) summary
      COG5126
      Location:68 → 234
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    5. NM_027398.5 → NP_081674.2  A-type potassium channel modulatory protein KCNIP1 isoform B

      See identical proteins and their annotated locations for NP_081674.2

      Status: VALIDATED

      Source sequence(s)
      AL669814, AL731867
      Consensus CDS
      CCDS24537.1
      UniProtKB/TrEMBL
      Q3YAB4, Q3YAB6
      Related
      ENSMUSP00000069063.6, ENSMUST00000065970.6
      Conserved Domains (1) summary
      COG5126
      Location:39 → 205
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      33579339..33943854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314753.3 → XP_017170242.1  Kv channel-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A571BET8
      Conserved Domains (1) summary
      COG5126
      Location:48 → 218
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. XM_036156977.1 → XP_036012870.1  Kv channel-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      Q3YAB4
      Conserved Domains (1) summary
      COG5126
      Location:11 → 177
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    3. XM_036156976.1 → XP_036012869.1  Kv channel-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      Q3YAB4
      Conserved Domains (1) summary
      COG5126
      Location:11 → 177
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    4. XM_017314754.2 → XP_017170243.1  Kv channel-interacting protein 1 isoform X4

      UniProtKB/TrEMBL
      Q3YAB4
      Conserved Domains (1) summary
      COG5126
      Location:39 → 209
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    5. XM_017314752.2 → XP_017170241.1  Kv channel-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      Q3YAB4
      Conserved Domains (1) summary
      COG5126
      Location:50 → 220
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    6. XM_030246299.1 → XP_030102159.1  Kv channel-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      Q3YAB4
      Conserved Domains (1) summary
      COG5126
      Location:11 → 177
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    7. XM_030246297.1 → XP_030102157.1  Kv channel-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      Q3YAB4
      Conserved Domains (1) summary
      COG5126
      Location:11 → 177
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    8. XM_017314755.3 → XP_017170244.1  Kv channel-interacting protein 1 isoform X5

      UniProtKB/TrEMBL
      Q3YAB4
      Conserved Domains (1) summary
      COG5126
      Location:11 → 181
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    9. XM_030246298.2 → XP_030102158.1  Kv channel-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      Q3YAB4
      Conserved Domains (1) summary
      COG5126
      Location:11 → 177
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    10. XM_017314751.3 → XP_017170240.1  Kv channel-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A571BET8
      Conserved Domains (1) summary
      COG5126
      Location:68 → 238
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    11. XM_036156978.1 → XP_036012871.1  Kv channel-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      Q3YAB4
      Conserved Domains (1) summary
      COG5126
      Location:11 → 177
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJ57.2 GenPept UniProtKB/Swiss-Prot:Q9JJ57

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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