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    Golm1 golgi membrane protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 105348, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Golm1provided by MGI
    Official Full Name
    golgi membrane protein 1provided by MGI
    Primary source
    MGI:MGI:1917329
    See related
    Ensembl:ENSMUSG00000021556 AllianceGenome:MGI:1917329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GP73; Golph2; PSEC0257; 2310001L02Rik; D030064E01Rik
    Summary
    Acts upstream of or within nucleus organization and regulation of lipid metabolic process. Located in Golgi apparatus. Is expressed in rectum. Orthologous to human GOLM1 (golgi membrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in colon adult (RPKM 65.4), large intestine adult (RPKM 43.3) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Golm1 in Genome Data Viewer
    Location:
    13 B2; 13 31.87 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (59782810..59823598, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (59634996..59675784, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A230056J06 gene Neighboring gene STARR-seq mESC enhancer starr_34713 Neighboring gene N(alpha)-acetyltransferase 35, NatC auxiliary subunit Neighboring gene STARR-seq mESC enhancer starr_34715 Neighboring gene STARR-seq mESC enhancer starr_34717 Neighboring gene STARR-seq mESC enhancer starr_34719 Neighboring gene RIKEN cDNA 4921517D22 gene Neighboring gene spermatogenesis associated 31 subfamily D, member 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1. Wang Y, et al. Am J Respir Cell Mol Biol, 2024 Mar. PMID 38029327
    2. Deletion of Golgi protein 73 delayed hepatocyte proliferation of mouse in the early stages of liver regeneration. Wang J, et al. J Gastroenterol Hepatol, 2021 May. PMID 33119928
    3. GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity. Peng Y, et al. Nat Commun, 2021 Dec 1. PMID 34853313, Free PMC Article
    4. GOLM1 suppresses autophagy-mediated anti-tumor immunity in hepatocellular carcinoma. Sui T, et al. Signal Transduct Target Ther, 2021 Sep 17. PMID 34531366, Free PMC Article
    5. Causal Association of Golgi Protein 73 With Coronary Artery Disease: Evidence from Proteomics and Mendelian Randomization. Lin YF, et al. Int J Med Sci, 2024. PMID 39239555, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Causal Association of Golgi Protein 73 With Coronary Artery Disease: Evidence from Proteomics and Mendelian Randomization.
      Title: Causal Association of Golgi Protein 73 With Coronary Artery Disease: Evidence from Proteomics and Mendelian Randomization.
    2. PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1.
      Title: PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1.
    3. Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress.
      Title: Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress.
    4. GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1.
      Title: GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1.
    5. Golgi Protein 73 Promotes LPS-Induced Cardiac Dysfunction via Mediating Myocardial Apoptosis and Autophagy.
      Title: Golgi Protein 73 Promotes LPS-Induced Cardiac Dysfunction via Mediating Myocardial Apoptosis and Autophagy.
    6. GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling.
      Title: GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling.
    7. GOLM1 suppresses autophagy-mediated anti-tumor immunity in hepatocellular carcinoma.
      Title: GOLM1 suppresses autophagy-mediated anti-tumor immunity in hepatocellular carcinoma.
    8. GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis.
      Title: GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis.
    9. GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia.
      Title: GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia.
    10. GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity.
      Title: GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (2) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107447

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Golgi membrane protein 1
    Names
    golgi membrane protein GP73
    golgi phosphoprotein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035122.2 → NP_001030294.1  Golgi membrane protein 1

      See identical proteins and their annotated locations for NP_001030294.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment in the 5' UTR, compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AK051066, AK167646, CK391733, CN529028, DV645181
      Consensus CDS
      CCDS26576.1
      UniProtKB/Swiss-Prot
      G3X8U4, Q91XA2
      UniProtKB/TrEMBL
      Q3UZG0
      Related
      ENSMUSP00000022039.6, ENSMUST00000022039.7
      Conserved Domains (1) summary
      cl23887
      Location:106 → 211
      DUF4349; Domain of unknown function (DUF4349)

    2. NM_027307.4 → NP_081583.3  Golgi membrane protein 1

      See identical proteins and their annotated locations for NP_081583.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AK009072, AK051066, BU152451, CD552063, CD560663, CK391733
      Consensus CDS
      CCDS26576.1
      UniProtKB/Swiss-Prot
      G3X8U4, Q91XA2
      UniProtKB/TrEMBL
      Q3UZG0
      Related
      ENSMUSP00000093410.3, ENSMUST00000095739.10
      Conserved Domains (1) summary
      cl23887
      Location:106 → 211
      DUF4349; Domain of unknown function (DUF4349)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      59782810..59823598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XA2.2 GenPept UniProtKB/Swiss-Prot:Q91XA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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