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    Septin3 septin 3 [ Mus musculus (house mouse) ]

    Gene ID: 24050, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Septin3provided by MGI
    Official Full Name
    septin 3provided by MGI
    Primary source
    MGI:MGI:1345148
    See related
    Ensembl:ENSMUSG00000022456 AllianceGenome:MGI:1345148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sep3; Sept3; Gm46500; 3110018K01Rik; B530002E20Rik
    Summary
    Predicted to enable several functions, including GTP binding activity; GTPase activity; and identical protein binding activity. Involved in protein catabolic process at presynapse. Part of septin complex. Is active in presynapse. Is expressed in several structures, including central nervous system; peripheral nervous system ganglion; sensory organ; somite; and testis. Orthologous to human SEPTIN3 (septin 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E14 (RPKM 82.2), whole brain E14.5 (RPKM 81.1) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Septin3 in Genome Data Viewer
    Location:
    15 E1; 15 38.56 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82153003..82178775)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82268802..82294574)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene centromere protein M Neighboring gene STARR-positive B cell enhancer ABC_E8601 Neighboring gene STARR-seq mESC enhancer starr_39290 Neighboring gene small integral membrane protein 45 Neighboring gene predicted gene, 52180 Neighboring gene STARR-seq mESC enhancer starr_39292 Neighboring gene WBP2 N-terminal like Neighboring gene N-acetyl galactosaminidase, alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeted disruption of Sept3, a heteromeric assembly partner of Sept5 and Sept7 in axons, has no effect on developing CNS neurons. Fujishima K, et al. J Neurochem, 2007 Jul. PMID 17564677
    2. Retroviral promoter-trap insertion into a novel mammalian septin gene expressed during mouse neuronal development. Xiong JW, et al. Mech Dev, 1999 Aug. PMID 10446280
    3. Large-scale screening for developmental genes in embryonic stem cells and embryoid bodies using retroviral entrapment vectors. Xiong JW, et al. Dev Dyn, 1998 Jun. PMID 9626494
    4. Neuronal-specific septin-3 binds Atg8/LC3B, accumulates and localizes to autophagosomes during induced autophagy. Tóth V, et al. Cell Mol Life Sci, 2022 Aug 6. PMID 35932293, Free PMC Article
    5. Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22. Hentges KE, et al. Genomics, 2002 Aug. PMID 12160734

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SEPT3 and SEPT5 are dispensable for neuronal development as well as for synaptic vesicle fusion and recycling.
      Title: Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission.
    2. Sept3 is dispensable for normal neuronal development
      Title: Targeted disruption of Sept3, a heteromeric assembly partner of Sept5 and Sept7 in axons, has no effect on developing CNS neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein catabolic process at presynapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in protein catabolic process at presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein catabolic process at presynapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein catabolic process at presynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neuronal-specific septin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358836.2 → NP_001345765.1  neuronal-specific septin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC104325
      Conserved Domains (1) summary
      cd01850
      Location:59 → 333
      CDC_Septin; CDC/Septin GTPase family

    2. NM_001358837.2 → NP_001345766.1  neuronal-specific septin-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104325
      Conserved Domains (1) summary
      cd01850
      Location:59 → 333
      CDC_Septin; CDC/Septin GTPase family

    3. NM_001368642.1 → NP_001355571.1  neuronal-specific septin-3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC104325
      UniProtKB/Swiss-Prot
      Q3TNZ2, Q7TNT7, Q9Z1S5
      Conserved Domains (1) summary
      cd01850
      Location:59 → 333
      CDC_Septin; CDC/Septin GTPase family

    4. NM_001368643.1 → NP_001355572.1  neuronal-specific septin-3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC104325
      Conserved Domains (1) summary
      cd01850
      Location:59 → 332
      CDC_Septin; CDC/Septin GTPase family

    5. NM_001368644.1 → NP_001355573.1  neuronal-specific septin-3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC104325
      Conserved Domains (1) summary
      cd01850
      Location:46 → 320
      CDC_Septin; CDC/Septin GTPase family

    6. NM_001368645.1 → NP_001355574.1  neuronal-specific septin-3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC104325
      Consensus CDS
      CCDS88814.1
      UniProtKB/TrEMBL
      A0A2R8W6V9
      Related
      ENSMUSP00000155480.2, ENSMUST00000230365.2
      Conserved Domains (1) summary
      cd01850
      Location:46 → 320
      CDC_Septin; CDC/Septin GTPase family

    7. NM_001368646.1 → NP_001355575.1  neuronal-specific septin-3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC104325
      Conserved Domains (1) summary
      cd01850
      Location:46 → 319
      CDC_Septin; CDC/Septin GTPase family

    8. NM_001368647.1 → NP_001355576.1  neuronal-specific septin-3 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC104325
      Conserved Domains (1) summary
      cd01850
      Location:4 → 269
      CDC_Septin; CDC/Septin GTPase family

    9. NM_001368784.1 → NP_001355713.1  neuronal-specific septin-3 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC104325
      Consensus CDS
      CCDS88813.1
      UniProtKB/TrEMBL
      A0A5F8MPL6
      Related
      ENSMUSP00000158860.2, ENSMUST00000239048.2
      Conserved Domains (1) summary
      cd01850
      Location:527 → 801
      CDC_Septin; CDC/Septin GTPase family

    10. NM_001368785.1 → NP_001355714.1  neuronal-specific septin-3 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC104325
      Consensus CDS
      CCDS88812.1
      UniProtKB/TrEMBL
      A0A571BE69
      Related
      ENSMUSP00000158597.2, ENSMUST00000238416.3
      Conserved Domains (1) summary
      cd01850
      Location:527 → 801
      CDC_Septin; CDC/Septin GTPase family

    11. NM_011889.4 → NP_036019.2  neuronal-specific septin-3 isoform 3

      See identical proteins and their annotated locations for NP_036019.2

      Status: VALIDATED

      Source sequence(s)
      AC104325
      Consensus CDS
      CCDS37157.1
      UniProtKB/Swiss-Prot
      Q9Z1S5
      Related
      ENSMUSP00000112124.2, ENSMUST00000116423.3
      Conserved Domains (1) summary
      cd01850
      Location:46 → 320
      CDC_Septin; CDC/Septin GTPase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      82153003..82178775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248568.2 → XP_030104428.1  neuronal-specific septin-3 isoform X1

      Conserved Domains (1) summary
      cd01850
      Location:527 → 801
      CDC_Septin; CDC/Septin GTPase family

    2. XM_036159411.1 → XP_036015304.1  neuronal-specific septin-3 isoform X2

      Conserved Domains (1) summary
      cd01850
      Location:143 → 416
      CDC_Septin; CDC/Septin GTPase family

    3. XM_030248570.1 → XP_030104430.1  neuronal-specific septin-3 isoform X2

      Conserved Domains (1) summary
      cd01850
      Location:143 → 416
      CDC_Septin; CDC/Septin GTPase family

    4. XM_030248571.1 → XP_030104431.1  neuronal-specific septin-3 isoform X3

      UniProtKB/TrEMBL
      A0A2R8W6V9
      Conserved Domains (1) summary
      cd01850
      Location:46 → 320
      CDC_Septin; CDC/Septin GTPase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1S5.2 GenPept UniProtKB/Swiss-Prot:Q9Z1S5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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