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    Zfp146 zinc finger protein 146 [ Mus musculus (house mouse) ]

    Gene ID: 26465, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp146provided by MGI
    Official Full Name
    zinc finger protein 146provided by MGI
    Primary source
    MGI:MGI:1347092
    See related
    Ensembl:ENSMUSG00000037029 AllianceGenome:MGI:1347092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OZF; Znf146
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; eye; genitourinary system; and limb. Orthologous to human ZNF146 (zinc finger protein 146). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 33.5), CNS E14 (RPKM 24.6) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp146 in Genome Data Viewer
    Location:
    7 B1; 7 17.29 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29859912..29869225, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30160487..30169775, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 382 Neighboring gene STARR-seq mESC enhancer starr_18508 Neighboring gene zinc finger protein 334 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18509 Neighboring gene predicted gene 5113 Neighboring gene STARR-positive B cell enhancer ABC_E4914 Neighboring gene predicted gene, 53356 Neighboring gene cytochrome c oxidase subunit 7A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeted expression of the only zinc finger gene in transgenic mice is associated with impaired mammary development. Besnar N, et al. Transgenic Res, 2002 Oct. PMID 12437081
    2. Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and Zfp260 a closely related gene. Blottière L, et al. Cytogenet Cell Genet, 1999. PMID 10449921
    3. The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling. Debrus S, et al. Mol Cell Biol, 2005 Oct. PMID 16166646, Free PMC Article
    4. Global gene expression analysis of murine limb development. Taher L, et al. PLoS One, 2011. PMID 22174793, Free PMC Article
    5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein OZF
    Names
    only zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357557.1 → NP_001344486.1  zinc finger protein OZF

      Status: VALIDATED

      Source sequence(s)
      AC164703
      Consensus CDS
      CCDS21079.1
      UniProtKB/Swiss-Prot
      A0JNX3, Q8BQN6, Q9Z0Q5
      Conserved Domains (3) summary
      COG5048
      Location:1 → 260
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:214 → 234
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255 → 279
      zf-H2C2_2; Zinc-finger double domain

    2. NM_011980.4 → NP_036110.1  zinc finger protein OZF

      See identical proteins and their annotated locations for NP_036110.1

      Status: VALIDATED

      Source sequence(s)
      AC164703
      Consensus CDS
      CCDS21079.1
      UniProtKB/Swiss-Prot
      A0JNX3, Q8BQN6, Q9Z0Q5
      Related
      ENSMUSP00000058588.8, ENSMUST00000062181.9
      Conserved Domains (3) summary
      COG5048
      Location:1 → 260
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:214 → 234
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255 → 279
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29859912..29869225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540008.4 → XP_006540071.1  zinc finger protein OZF isoform X1

      See identical proteins and their annotated locations for XP_006540071.1

      UniProtKB/Swiss-Prot
      A0JNX3, Q8BQN6, Q9Z0Q5
      Conserved Domains (3) summary
      COG5048
      Location:1 → 260
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:214 → 234
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255 → 279
      zf-H2C2_2; Zinc-finger double domain

    2. XM_036153136.1 → XP_036009029.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      A0JNX3, Q8BQN6, Q9Z0Q5
      Conserved Domains (3) summary
      COG5048
      Location:1 → 260
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:214 → 234
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255 → 279
      zf-H2C2_2; Zinc-finger double domain

    3. XM_036153137.1 → XP_036009030.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      A0JNX3, Q8BQN6, Q9Z0Q5
      Conserved Domains (3) summary
      COG5048
      Location:1 → 260
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:214 → 234
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255 → 279
      zf-H2C2_2; Zinc-finger double domain

    4. XM_030242608.2 → XP_030098468.1  zinc finger protein OZF isoform X1

      UniProtKB/Swiss-Prot
      A0JNX3, Q8BQN6, Q9Z0Q5
      Conserved Domains (3) summary
      COG5048
      Location:1 → 260
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:214 → 234
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255 → 279
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQN6.2 GenPept UniProtKB/Swiss-Prot:Q8BQN6

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