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    St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25547, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St8sia3provided by RGD
    Official Full Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3provided by RGD
    Primary source
    RGD:3680
    See related
    EnsemblRapid:ENSRNOG00000018305 AllianceGenome:RGD:3680
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Siat8c
    Summary
    Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity and identical protein binding activity. Predicted to be involved in several processes, including N-glycan processing; ganglioside biosynthetic process; and sialylation. Predicted to be located in Golgi membrane. Orthologous to human ST8SIA3 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 122.4), Liver (RPKM 72.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See St8sia3 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (60024555..60031050)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (57754349..57760839)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (59748766..59755257)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene peroxiredoxin 1, pseudogene 4 Neighboring gene uncharacterized LOC102553013 Neighboring gene RGD1562699 Neighboring gene one cut homeobox 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation. Volkers G, et al. Nat Struct Mol Biol, 2015 Aug. PMID 26192331
    2. Cloning and expression of cDNA for a human Sia alpha 2,3Gal beta 1, 4GlcNA:alpha 2,8-sialyltransferase (hST8Sia III). Lee YC, et al. Arch Biochem Biophys, 1998 Dec 1. PMID 9826427
    3. Cloning of the cDNA coding for rat brain CMP-NeuAc:GD3 alpha2-8 sialyltransferase. Zeng G, et al. Gene, 1997 Mar 10. PMID 9073076
    4. Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain. Yoshida Y, et al. J Biol Chem, 1995 Jun 16. PMID 7782326
    5. Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. Angata K, et al. J Biol Chem, 2000 Jun 16. PMID 10766765

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-glycan processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ganglioside biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligosaccharide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sialylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
    Names
    GT3-synthase
    ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 3
    Sialyltransferase 8 (GT3 alpha 2,8-sialyltransferase) C
    Sialyltransferase 8 (GT3 alpha 28-sialyltransferase) C
    sialyltransferase 8 C
    NP_037161.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013029.2 → NP_037161.2  sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6IXN4, G3V8D0, P97877
      Related
      ENSRNOP00000024752.2, ENSRNOT00000024752.6
      Conserved Domains (1) summary
      pfam00777
      Location:113 → 376
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      60024555..60031050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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