Carm1 coactivator-associated arginine methyltransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Carm1provided by MGI
Official Full Name: coactivator-associated arginine methyltransferase 1provided by MGI
Primary source: MGI:MGI:1913208
See related: Ensembl:ENSMUSG00000032185 AllianceGenome:MGI:1913208
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prmt4; m9Bei
Summary: Enables several functions, including lysine-acetylated histone binding activity; nuclear receptor coactivator activity; and protein-arginine N-methyltransferase activity. Involved in nuclear receptor-mediated steroid hormone signaling pathway; positive regulation of fat cell differentiation; and regulation of intracellular estrogen receptor signaling pathway. Acts upstream of or within several processes, including estrogen receptor signaling pathway; regulation of DNA-templated transcription; and regulation of growth plate cartilage chondrocyte proliferation. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; gonad; and sensory organ. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 59.4), limb E14.5 (RPKM 52.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9; 9 A3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (21458163..21500763)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (21546894..21589467)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease.
Title: Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease.
Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1.
Title: Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1.
CARM1 arginine methyltransferase as a therapeutic target for cancer.
Title: CARM1 arginine methyltransferase as a therapeutic target for cancer.
Sex-Specific Effect of CARM1 in Skeletal Muscle Adaptations to Exercise.
Title: Sex-Specific Effect of CARM1 in Skeletal Muscle Adaptations to Exercise.
Arginine methylation of PPP1CA by CARM1 regulates glucose metabolism and affects osteogenic differentiation and osteoclastic differentiation.
Title: Arginine methylation of PPP1CA by CARM1 regulates glucose metabolism and affects osteogenic differentiation and osteoclastic differentiation.
PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARgamma.
Title: PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ.
Role of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in the Regulation of the Biological Function of 1,25-Dihydroxyvitamin D3.
Title: Role of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in the Regulation of the Biological Function of 1,25-Dihydroxyvitamin D(3).
The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer.
Title: The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer.
The CARM1 transcriptome and arginine methylproteome mediate skeletal muscle integrative biology.
Title: The CARM1 transcriptome and arginine methylproteome mediate skeletal muscle integrative biology.
The arginine methyltransferase Carm1 is necessary for heart development.
Title: The arginine methyltransferase Carm1 is necessary for heart development.

Submit: New GeneRIF Correction See all GeneRIFs (61)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4)
Gene trapped (1)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Carm1 (e-PCR), detects polymorphism
- UniSTS:515959

Carm1 (e-PCR), detects polymorphism
- UniSTS:479133

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H2AQ104 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K37 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R17 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3R2 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3R2 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3R2 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3R26 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3R8 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K12 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4R3 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone arginine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables lysine-acetylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein-arginine omega-N asymmetric methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endochondral bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within estrogen receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dendrite development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear receptor-mediated steroid hormone signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein localization to chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of growth plate cartilage chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of intracellular estrogen receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in replication fork reversal	ISO Inferred from Sequence Orthology more info
involved_in replication fork reversal	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cAMP	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nuclear replication fork	ISO Inferred from Sequence Orthology more info
is_active_in nuclear replication fork	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone-arginine methyltransferase CARM1

Names: protein arginine N-methyltransferase 4; protein arginine methyltransferase

NP_001398162.1

EC 2.1.1.319

NP_067506.2

EC 2.1.1.319

NP_694781.1

EC 2.1.1.319

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411233.1 → NP_001398162.1 histone-arginine methyltransferase CARM1 isoform 3

Status: VALIDATED

Source sequence(s)

AC163748
NM_021531.6 → NP_067506.2 histone-arginine methyltransferase CARM1 isoform 1

See identical proteins and their annotated locations for NP_067506.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

AK158242, AK158757, BU152197, BX529415

Consensus CDS

CCDS22906.1

UniProtKB/Swiss-Prot

Q3TYB9, Q8K1Y5, Q91W24, Q99KX8, Q9WVG6

UniProtKB/TrEMBL

D3YUP1

Related

ENSMUSP00000034703.9, ENSMUST00000034703.15

Conserved Domains (2) summary

cd02440
Location:189 → 284

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

pfam11531
Location:35 → 139

CARM1; Coactivator-associated arginine methyltransferase 1 N terminal
NM_153141.1 → NP_694781.1 histone-arginine methyltransferase CARM1 isoform 2

See identical proteins and their annotated locations for NP_694781.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AC163748

Consensus CDS

CCDS52736.1

UniProtKB/TrEMBL

D3YUP1

Related

ENSMUSP00000111053.4, ENSMUST00000115395.10

Conserved Domains (2) summary

cd02440
Location:189 → 284

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

pfam11531
Location:35 → 139

CARM1; Coactivator-associated arginine methyltransferase 1 N terminal