CRISP3 cysteine rich secretory protein 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CRISP3provided by HGNC
Official Full Name: cysteine rich secretory protein 3provided by HGNC
Primary source: HGNC:HGNC:16904
See related: Ensembl:ENSG00000096006 MIM:618062; AllianceGenome:HGNC:16904
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Aeg2; CRS3; SGP28; CRISP-3; dJ442L6.3
Summary: This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Expression: Biased expression in salivary gland (RPKM 504.8), bone marrow (RPKM 138.4) and 1 other tissue See more
Orthologs: all
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Genomic context

Location:: 6p12.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (49727376..49744388, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (49569352..49586363, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (49695089..49712101, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EP300 promotes tumor stemness via epigenetic activation of CRISP3 leading to lobaplatin resistance in triple-negative breast cancer.
Title: EP300 promotes tumor stemness via epigenetic activation of CRISP3 leading to lobaplatin resistance in triple-negative breast cancer.
In this study, we found obvious differences in the expression of CRISP3 between different mammary carcinoma cells, which is related to the prognosis of patients with mammary carcinoma
Title: Low expression of CRISP3 predicts a favorable prognosis in patients with mammary carcinoma.
in the presence of varicocoele, there is a marked increase in seminal CRISP-3 levels. Surgical intervention (varicocelectomy) decreases CRISP-3 levels and improves semen quality.
Title: Cysteine-rich secretory protein 3: inflammation role in adult varicocoele.
results suggest that overexpression of CRISP-3 in prostate tumor may maintain higher PSA expression and lower ANXA1 expression
Title: Cysteine-rich secretory protein 3 plays a role in prostate cancer cell invasion and affects expression of PSA and ANXA1.
These data suggest roles for epithelial and neutrophil-derived CRISP3 in postmenstrual endometrial repair and regeneration
Title: Endometrial CRISP3 is regulated throughout the mouse estrous and human menstrual cycle and facilitates adhesion and proliferation of endometrial epithelial cells.
up-regulation of the mRNA encoding cysteine-rich secretory protein 3 (CRISP3), a glycoprotein with unknown function that is secreted from multiple exocrine glands, was correlated with HCV resistance.
Title: Cysteine-rich secretory protein 3 inhibits hepatitis C virus at the initial phase of infection.
Strong CRISP3 expression is associated with unfavorable tumor phenotype and early recurrence in prostate cancers
Title: Cysteine-rich secretory protein 3 overexpression is linked to a subset of PTEN-deleted ERG fusion-positive prostate cancers with early biochemical recurrence.
terminal beta-strands of PSP94 contact the first alpha-helix and the hinge region of CRISP-3
Title: Mapping of the binding sites involved in PSP94-CRISP-3 interaction by molecular dissection of the complex.
MSMB and CRISP3 were widely distributed in ovaries and in ovarian tumors; the expression of MSMB fits well with a tumor-suppressor function in ovarian carcinogenesis.
Title: The expression of β-microseminoprotein but not CRISP3 is reduced in ovarian cancer and correlates to survival.
up-regulation of CRISP3 is associated with prostate carcinomas with the TMPRSS2-ERG fusion gene.
Title: Cysteine-rich secretory protein-3 (CRISP3) is strongly up-regulated in prostate carcinomas with the TMPRSS2-ERG fusion gene.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-X95240 (e-PCR)
- UniSTS:1026

NoName (e-PCR)
- UniSTS:481539

D6S1504 (e-PCR)
- UniSTS:19388

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response	NAS Non-traceable Author Statement more info	PubMed
involved_in innate immune response	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in specific granule	IDA Inferred from Direct Assay more info	PubMed
located_in specific granule lumen	TAS Traceable Author Statement more info
located_in tertiary granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: cysteine-rich secretory protein 3

Names: specific granule protein (28 kDa)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190986.3 → NP_001177915.1 cysteine-rich secretory protein 3 isoform 2

See identical proteins and their annotated locations for NP_001177915.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2 which is longer than isoform 1.

Source sequence(s)

AL121950, BC069580, DB206136, X95240

Consensus CDS

CCDS55019.1

UniProtKB/Swiss-Prot

A8K9S1, B2R8I8, P54108, Q15512, Q3MJ82, Q53FA9, Q5JW83, Q9H108

Related

ENSP00000389026.2, ENST00000433368.6

Conserved Domains (2) summary

cd05383
Location:60 → 197

SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...

pfam08562
Location:214 → 268

Crisp; Crisp
NM_001368123.1 → NP_001355052.1 cysteine-rich secretory protein 3 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) encodes the longest isoform (3).

Source sequence(s)

AL121950, AL121974, DB204588

Consensus CDS

CCDS93932.1

UniProtKB/Swiss-Prot

A8K9S1, B2R8I8, P54108, Q15512, Q3MJ82, Q53FA9, Q5JW83, Q9H108

UniProtKB/TrEMBL

J3KPA1

Related

ENSP00000360201.4, ENST00000371159.8
NM_006061.4 → NP_006052.2 cysteine-rich secretory protein 3 isoform 1

See identical proteins and their annotated locations for NP_006052.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AL121950, DB210604, X95240

Consensus CDS

CCDS4929.2

UniProtKB/Swiss-Prot

A8K9S1, B2R8I8, P54108, Q15512, Q3MJ82, Q53FA9, Q5JW83, Q9H108

Related

ENSP00000263045.4, ENST00000263045.9

Conserved Domains (2) summary

cd05383
Location:50 → 187

SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...

pfam08562
Location:204 → 258

Crisp; Crisp