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    PTMA prothymosin alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 786336, updated on 29-Jan-2025

    Summary

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    Gene symbol
    PTMA
    Gene description
    prothymosin alpha
    See related
    BGD:BT14957; Ensembl:ENSBTAG00000002549
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PTMA in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (119414085..119419153)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112443160 Neighboring gene uncharacterized LOC101905734 Neighboring gene phosphodiesterase 6D Neighboring gene phosphoglycerate mutase 1-like Neighboring gene transfer RNA lysine (anticodon UUU)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The amino acid sequence of bovine thymus prothymosin alpha. Panneerselvam C, et al. Arch Biochem Biophys, 1988 Sep. PMID 2901823
    2. The chemistry and biology of thymosin. II. Amino acid sequence analysis of thymosin alpha1 and polypeptide beta1. Low TL, et al. J Biol Chem, 1979 Feb 10. PMID 762108
    3. Prothymosin alpha is phosphorylated by casein kinase-2. Barcia MG, et al. FEBS Lett, 1992 Nov 9. PMID 1426245
    4. Phosphorylation of human and bovine prothymosin alpha in vivo. Sburlati AR, et al. Biochemistry, 1993 May 4. PMID 8485135
    5. Prothymosin alpha interacts with the CREB-binding protein and potentiates transcription. Karetsou Z, et al. EMBO Rep, 2002 Apr. PMID 11897665, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prothymosin alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      119414085..119419153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002685597.7 → XP_002685643.3  prothymosin alpha isoform X1

      See identical proteins and their annotated locations for XP_002685643.3

      UniProtKB/TrEMBL
      A0AAF6YK23
      Related
      ENSBTAP00070014205.1, ENSBTAT00070023924.1
      Conserved Domains (1) summary
      pfam03247
      Location:2 → 110
      Prothymosin; Prothymosin/parathymosin family

    2. XM_003585780.3 → XP_003585828.1  prothymosin alpha isoform X2

      See identical proteins and their annotated locations for XP_003585828.1

      UniProtKB/Swiss-Prot
      P01252
      Related
      ENSBTAP00070014201.1, ENSBTAT00070023918.1
      Conserved Domains (1) summary
      pfam03247
      Location:2 → 109
      Prothymosin; Prothymosin/parathymosin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01252.2 GenPept UniProtKB/Swiss-Prot:P01252

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