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    BCL2L2 BCL2 like 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 767601, updated on 27-Dec-2024

    Summary

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    Official Symbol
    BCL2L2provided by VGNC
    Official Full Name
    BCL2 like 2provided by VGNC
    Primary source
    VGNC:VGNC:55105
    See related
    BGD:BT13347; Ensembl:ENSBTAG00000019692
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    RELA
    Orthologs
    human mouse all
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    Genomic context

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    See BCL2L2 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (21596691..21606907, complement)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene embryonal Fyn-associated substrate Neighboring gene solute carrier family 22 member 17 Neighboring gene poly(A) binding protein nuclear 1 Neighboring gene protein phosphatase 1 regulatory subunit 3E Neighboring gene homeobox and leucine zipper encoding

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Assignment of the bovine BCL2-like 2 gene (BCL2L2) to BTA10q15-->q21 by in situ hybridization and with somatic cell hybrids. Martín-Burriel I, et al. Cytogenet Genome Res, 2006. PMID 16276654
    2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chromosome mapping of BCL2L2 gene in cows.
      Title: Assignment of the bovine BCL2-like 2 gene (BCL2L2) to BTA10q15-->q21 by in situ hybridization and with somatic cell hybrids.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bcl-2-like protein 2
    Names
    apoptosis regulator Bcl-W
    bcl2-L-2
    v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076533.1 → NP_001070001.1  bcl-2-like protein 2

      See identical proteins and their annotated locations for NP_001070001.1

      Status: PROVISIONAL

      Source sequence(s)
      BC114652
      UniProtKB/Swiss-Prot
      Q1RMX3
      UniProtKB/TrEMBL
      Q05KI8
      Conserved Domains (1) summary
      TIGR00865
      Location:11 → 193
      bcl-2; apoptosis regulator

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      21596691..21606907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024997871.2 → XP_024853639.1  bcl-2-like protein 2 isoform X1

      Conserved Domains (1) summary
      TIGR00865
      Location:11 → 144
      bcl-2; apoptosis regulator

    2. XM_024997870.2 → XP_024853638.1  bcl-2-like protein 2 isoform X1

      Conserved Domains (1) summary
      TIGR00865
      Location:11 → 144
      bcl-2; apoptosis regulator

    3. XM_005211399.5 → XP_005211456.1  bcl-2-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_005211456.1

      UniProtKB/Swiss-Prot
      Q1RMX3
      UniProtKB/TrEMBL
      Q05KI8
      Conserved Domains (1) summary
      TIGR00865
      Location:11 → 193
      bcl-2; apoptosis regulator

    4. XM_059890676.1 → XP_059746659.1  bcl-2-like protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q1RMX3
      UniProtKB/TrEMBL
      Q05KI8
      Related
      ENSBTAP00000026248.4, ENSBTAT00000026248.6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1RMX3.1 GenPept UniProtKB/Swiss-Prot:Q1RMX3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.