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    HSPA8 heat shock protein family A (Hsp70) member 8 [ Bos taurus (domestic cattle) ]

    Gene ID: 281831, updated on 1-Jan-2025

    Summary

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    Official Symbol
    HSPA8provided by VGNC
    Official Full Name
    heat shock protein family A (Hsp70) member 8provided by VGNC
    Primary source
    VGNC:VGNC:54632
    See related
    BGD:BT12679; Ensembl:ENSBTAG00000013162
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    Hsc70; HSPA10
    Orthologs
    human mouse all
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    Genomic context

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    See HSPA8 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (33679011..33683436, complement)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL16-like Neighboring gene brain specific homeobox Neighboring gene small nucleolar RNA SNORD14 Neighboring gene small nucleolar RNA SNORD14 Neighboring gene CXADR like membrane protein Neighboring gene GRAM domain containing 1B Neighboring gene microRNA mir-2313

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein. Flaherty KM, et al. Nature, 1990 Aug 16. PMID 2143562
    2. Nucleotide sequence of the cDNA of a bovine 70 kilodalton heat shock cognate protein. DeLuca-Flaherty C, et al. Nucleic Acids Res, 1990 Sep 25. PMID 2216746, Free PMC Article
    3. Structural basis of the 70-kilodalton heat shock cognate protein ATP hydrolytic activity. II. Structure of the active site with ADP or ATP bound to wild type and mutant ATPase fragment. Flaherty KM, et al. J Biol Chem, 1994 Apr 29. PMID 8175707
    4. Structural replacement of active site monovalent cations by the epsilon-amino group of lysine in the ATPase fragment of bovine Hsc70. Wilbanks SM, et al. Biochemistry, 1998 May 19. PMID 9585559
    5. The hydroxyl of threonine 13 of the bovine 70-kDa heat shock cognate protein is essential for transducing the ATP-induced conformational change. Sousa MC, et al. Biochemistry, 1998 Nov 3. PMID 9799500

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single-particle fluorescence imaging tracks the dynamics of Hsc70 and its clathrin substrate in real time.
      Title: Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating.
    2. The interaction of the molecular chaperone Hsc70 (HSPA8) with recombinant PrP was investigated.
      Title: The binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper.
    3. Structure of clathrin coat with bound Hsc70 and auxilin.
      Title: Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.
    4. Elevated expression of bovine heat shock cognate (hsc)70 protein increases diabetes and inflammation following islet beta cell damage in a transgenic mouse model.
      Title: Transgenic expression of Hsc70 in pancreatic islets enhances autoimmune diabetes in response to beta cell damage.
    5. Coats assembled from recombinant clathrin are good substrates for ATP- and auxilin-dependent, Hsc70-catalyzed uncoating.
      Title: A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction.
    6. analysis of the formation of a stable complex between chaperonin-containing TCP-1 (CCT) and Hsc70
      Title: The structure of CCT-Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin.
    7. The structure of an Hsp110:Hsc70 nucleotide exchange complex, is reported.
      Title: Structure of the Hsp110:Hsc70 nucleotide exchange machine.
    8. studied the process of disassembly by using cryo-electron microscopy to identify the initial binding site of Hsc70 on clathrin-C58J baskets at pH 6, under which conditions disassembly does not proceed further. Hsc70 interactions involve two sites
      Title: Visualization of the binding of Hsc70 ATPase to clathrin baskets: implications for an uncoating mechanism.
    9. specific association between HSP73 and gentamicin may reduce the chaperone activity of HSP73 in vitro and/or in vivo
      Title: 73-kDa molecular chaperone HSP73 is a direct target of antibiotic gentamicin.
    10. report role of HSC70 in the regulation of NMT
      Title: N-myristoyltransferase inhibitor protein is homologous to heat shock cognate protein 70.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128130

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables clathrin-uncoating ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated autophagy translocation complex disassembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in clathrin coat disassembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in late endosomal microautophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein targeting to lysosome involved in chaperone-mediated autophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in slow axonal transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in presynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in terminal bouton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heat shock cognate 71 kDa protein
    Names
    Hsc70 ATPase
    heat shock 70 kDa protein 8
    heat shock 70kDa protein 8
    heat shock 70kd protein 10 (HSC71)
    heat shock cognate 71 kD protein
    NP_776770.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174345.4 → NP_776770.2  heat shock cognate 71 kDa protein

      See identical proteins and their annotated locations for NP_776770.2

      Status: PROVISIONAL

      Source sequence(s)
      BC105182
      UniProtKB/TrEMBL
      A0AAA9TJ30
      Related
      ENSBTAP00000098454.1, ENSBTAT00000133146.1
      Conserved Domains (2) summary
      cd10233
      Location:6 → 381
      HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
      PTZ00009
      Location:1 → 613
      PTZ00009; heat shock 70 kDa protein; Provisional

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      33679011..33683436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19120.2 GenPept UniProtKB/Swiss-Prot:P19120

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.