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    PSMC1 proteasome 26S subunit, ATPase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 506238, updated on 27-Dec-2024

    Summary

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    Official Symbol
    PSMC1provided by VGNC
    Official Full Name
    proteasome 26S subunit, ATPase 1provided by VGNC
    Primary source
    VGNC:VGNC:33454
    See related
    BGD:BT28222; Ensembl:ENSBTAG00000005426
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PSMC1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (101862203..101874844)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene tyrosyl-DNA phosphodiesterase 1 Neighboring gene potassium two pore domain channel subfamily K member 13 Neighboring gene uncharacterized LOC112448536 Neighboring gene uncharacterized LOC101907747 Neighboring gene NRDE-2, necessary for RNA interference, domain containing Neighboring gene uncharacterized LOC132346431

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Mapping, expression, and association study of the bovine PSMC1 gene. Guo H, et al. Biochem Genet, 2008 Jun. PMID 18247114
    2. Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and activation of the 26 S proteasome. Gillette TG, et al. J Biol Chem, 2008 Nov 14. PMID 18796432, Free PMC Article
    3. Investigation of the association of two candidate genes (H-FABP and PSMC1) with growth and carcass traits in Qinchuan beef cattle from China. Liang W, et al. Genet Mol Res, 2014 Mar 17. PMID 24668675
    4. Molecular and cellular roles of PI31 (PSMF1) protein in regulation of proteasome function. Li X, et al. J Biol Chem, 2014 Jun 20. PMID 24770418, Free PMC Article
    5. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thus, the results of our study suggest that the H-FABP and PSMC1 gene polymorphisms could be used as genetic markers in marker-assisted selection for improving Qinchuan beef cattle
      Title: Investigation of the association of two candidate genes (H-FABP and PSMC1) with growth and carcass traits in Qinchuan beef cattle from China.
    2. reveal critical roles of COOH termini of Rpt subunits of PA700 in the assembly and activation of eukaryotic 26 S proteasome[PA700 proteasome activator ]
      Title: Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and activation of the 26 S proteasome.
    3. data show that animals with AA genotype have a lower food intake, grow faster, are longer in the body & have less backfat & bigger loin muscle; PSMC1 gene was expressed mainly in lung, testis, and spleen; mapped PSMC1 gene on BTA10
      Title: Mapping, expression, and association study of the bovine PSMC1 gene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables proteasome-activating activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of proteasome regulatory particle, base subcomplex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    26S proteasome regulatory subunit 4
    Names
    proteasome (prosome, macropain) 26S subunit, ATPase, 1
    proteasome 26S ATPase subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014855.1 → NP_001014855.1  26S proteasome regulatory subunit 4

      Status: PROVISIONAL

      Source sequence(s)
      BT020983
      UniProtKB/TrEMBL
      Q5E9D7
      Related
      ENSBTAP00000007135.4, ENSBTAT00000007135.5
      Conserved Domains (4) summary
      PTZ00361
      Location:1 → 440
      PTZ00361; 26 proteosome regulatory subunit 4-like protein; Provisional
      pfam00004
      Location:222 → 355
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam10146
      Location:59 → 151
      zf-C4H2; Zinc finger-containing protein
      pfam16450
      Location:108 → 176
      Prot_ATP_ID_OB; Proteasomal ATPase OB/ID domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      101862203..101874844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024997342.2 → XP_024853110.1  26S proteasome regulatory subunit 4 isoform X1

      Conserved Domains (1) summary
      PTZ00361
      Location:1 → 367
      PTZ00361; 26 proteosome regulatory subunit 4-like protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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