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    PTPRU protein tyrosine phosphatase receptor type U [ Bos taurus (domestic cattle) ]

    Gene ID: 535675, updated on 29-Jan-2025

    Summary

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    Official Symbol
    PTPRUprovided by VGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Uprovided by VGNC
    Primary source
    VGNC:VGNC:33559
    See related
    BGD:BT24642; Ensembl:ENSBTAG00000012848
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PTPRU in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (124237184..124325678, complement)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343604 Neighboring gene uncharacterized LOC132343608 Neighboring gene U6 spliceosomal RNA Neighboring gene mitochondrial trans-2-enoyl-CoA reductase Neighboring gene serine and arginine rich splicing factor 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase U
    NP_001178423.1
    XP_005203276.1
    XP_024831930.1
    XP_024831937.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191494.1 → NP_001178423.1  receptor-type tyrosine-protein phosphatase U precursor

      See identical proteins and their annotated locations for NP_001178423.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000002
      UniProtKB/TrEMBL
      A0A3Q1LZM0, F1MD22
      Related
      ENSBTAP00070013748.1, ENSBTAT00070023317.1
      Conserved Domains (8) summary
      cd06263
      Location:27 → 186
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:1175 → 1438
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:196 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:923 → 1143
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:484 → 585
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:291 → 366
      fn3; Fibronectin type III domain
      pfam00102
      Location:918 → 1143
      Y_phosphatase; Protein-tyrosine phosphatase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      124237184..124325678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005203219.5 → XP_005203276.1  receptor-type tyrosine-protein phosphatase U isoform X3

      See identical proteins and their annotated locations for XP_005203276.1

      UniProtKB/TrEMBL
      A0A3Q1LZM0
      Conserved Domains (8) summary
      cd06263
      Location:27 → 186
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:1165 → 1428
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:196 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:913 → 1133
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:484 → 585
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:291 → 366
      fn3; Fibronectin type III domain
      pfam00102
      Location:908 → 1133
      Y_phosphatase; Protein-tyrosine phosphatase

    2. XM_024976169.2 → XP_024831937.1  receptor-type tyrosine-protein phosphatase U isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LZM0
      Related
      ENSBTAP00070013759.1, ENSBTAT00070023331.1
      Conserved Domains (6) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:196 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:1201 → 1434
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      pfam00102
      Location:908 → 1139
      Y_phosphatase; Protein-tyrosine phosphatase

    3. XM_024976162.2 → XP_024831930.1  receptor-type tyrosine-protein phosphatase U isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LZM0
      Conserved Domains (6) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:196 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:1211 → 1444
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      pfam00102
      Location:918 → 1149
      Y_phosphatase; Protein-tyrosine phosphatase
    Nucleotide Protein Strain
    Heading Accession and Version

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