U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MYOD1 myogenic differentiation 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281938, updated on 1-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    MYOD1provided by VGNC
    Official Full Name
    myogenic differentiation 1provided by VGNC
    Primary source
    VGNC:VGNC:31835
    See related
    BGD:BT16281; Ensembl:ENSBTAG00000002216
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    MyoD
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MYOD1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (34794120..34796767, complement)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene secretion regulating guanine nucleotide exchange factor Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene potassium voltage-gated channel subfamily C member 1 Neighboring gene otogelin Neighboring gene USH1 protein network component harmonin

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Variation in myogenic differentiation 1 mRNA abundance is associated with beef tenderness in Nelore cattle. Tizioto PC, et al. Anim Genet, 2016 Aug. PMID 27028139
    2. Hypoxia affects positively the proliferation of bovine satellite cells and their myogenic differentiation through up-regulation of MyoD. Kook SH, et al. Cell Biol Int, 2008 Aug. PMID 18468460
    3. Bovine CAPN3 core promoter initiates expression of foreign genes in skeletal muscle cells by MyoD transcriptional regulation. Ge L, et al. Int J Biochem Cell Biol, 2020 Oct. PMID 32827763
    4. Unlocking the Transcriptional Control of NCAPG in Bovine Myoblasts: CREB1 and MYOD1 as Key Players. Chen Z, et al. Int J Mol Sci, 2024 Feb 21. PMID 38473754, Free PMC Article
    5. Enhanced expression of MYF5 and MYOD1 in fibroblast cells via the forced expression of bos taurus MYF5. Nie YW, et al. Cell Biol Int, 2013 Sep. PMID 23640900

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unlocking the Transcriptional Control of NCAPG in Bovine Myoblasts: CREB1 and MYOD1 as Key Players.
      Title: Unlocking the Transcriptional Control of NCAPG in Bovine Myoblasts: CREB1 and MYOD1 as Key Players.
    2. Bovine CAPN3 core promoter initiates expression of foreign genes in skeletal muscle cells by MyoD transcriptional regulation.
      Title: Bovine CAPN3 core promoter initiates expression of foreign genes in skeletal muscle cells by MyoD transcriptional regulation.
    3. Transcript abundance for the muscle regulatory gene MYOD1 was lower in animals with more tender beef.
      Title: Variation in myogenic differentiation 1 mRNA abundance is associated with beef tenderness in Nelore cattle.
    4. Bos taurus MYF5 activates MYF5 and MYOD1 expression in cultured fibroblasts.
      Title: Enhanced expression of MYF5 and MYOD1 in fibroblast cells via the forced expression of bos taurus MYF5.
    5. n conclusion, hypoxia stimulates the proliferation of satellite cells and promotes their myogenic differentiation with MyoD playing an important role
      Title: Hypoxia affects positively the proliferation of bovine satellite cells and their myogenic differentiation through up-regulation of MyoD.
    6. results suggest that MyoD and Myf5 influence the MyHC isoform expression, although the effects are not decisive in specifying the phenotypes of adult muscles
      Title: Related expression of MyoD and Myf5 with myosin heavy chain isoform types in bovine adult skeletal muscles.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC143434

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in skeletal muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    myoblast determination protein 1
    Names
    myogenic differenciation 1, transcription activator
    myogenic factor 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040478.2 → NP_001035568.2  myoblast determination protein 1

      See identical proteins and their annotated locations for NP_001035568.2

      Status: PROVISIONAL

      Source sequence(s)
      BC120454
      UniProtKB/Swiss-Prot
      Q7YS82
      UniProtKB/TrEMBL
      Q0VBX9
      Related
      ENSBTAP00000002868.3, ENSBTAT00000002868.4
      Conserved Domains (3) summary
      smart00520
      Location:19 → 114
      BASIC; Basic domain in HLH proteins of MYOD family
      pfam00010
      Location:110 → 161
      HLH; Helix-loop-helix DNA-binding domain
      pfam12232
      Location:191 → 259
      Myf5; Myogenic determination factor 5

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      34794120..34796767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YS82.1 GenPept UniProtKB/Swiss-Prot:Q7YS82

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.