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    PTPRZ1 protein tyrosine phosphatase receptor type Z1 [ Bos taurus (domestic cattle) ]

    Gene ID: 317725, updated on 1-Jan-2025

    Summary

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    Official Symbol
    PTPRZ1provided by VGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Z1provided by VGNC
    Primary source
    VGNC:VGNC:33560
    See related
    BGD:BT12681; Ensembl:ENSBTAG00000012119
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PTPRZ1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (86301191..86511065)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112446337 Neighboring gene uncharacterized LOC132345187 Neighboring gene aminoadipate-semialdehyde synthase Neighboring gene small ribosomal subunit protein uS5-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Brain-specific receptor-type protein-tyrosine phosphatase RPTP beta is a chondroitin sulfate proteoglycan in vivo. Shitara K, et al. J Biol Chem, 1994 Aug 5. PMID 8051107
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC179578

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase zeta
    Names
    protein tyrosine phosphatase, receptor-type, Z polypeptide 1
    NP_001179201.1
    XP_010802704.1
    XP_010802705.1
    XP_010802706.1
    XP_010802707.1
    XP_024846259.1
    XP_024846260.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192272.4 → NP_001179201.1  receptor-type tyrosine-protein phosphatase zeta precursor

      See identical proteins and their annotated locations for NP_001179201.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000004
      UniProtKB/TrEMBL
      F1MGK5
      Conserved Domains (4) summary
      smart00194
      Location:1725 → 2000
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1761 → 2000
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd03122
      Location:45 → 298
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
      pfam00041
      Location:313 → 401
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      86301191..86511065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010804404.3 → XP_010802706.1  receptor-type tyrosine-protein phosphatase zeta isoform X5

      UniProtKB/TrEMBL
      A0A3Q1LP12
      Related
      ENSBTAP00000058748.2, ENSBTAT00000078531.2
      Conserved Domains (5) summary
      smart00194
      Location:863 → 1138
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:899 → 1138
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd03122
      Location:45 → 298
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
      pfam00041
      Location:313 → 401
      fn3; Fibronectin type III domain
      cl17169
      Location:486 → 691
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_010804405.3 → XP_010802707.1  receptor-type tyrosine-protein phosphatase zeta isoform X6

      UniProtKB/TrEMBL
      A0A3Q1LP12
      Conserved Domains (5) summary
      smart00194
      Location:863 → 1131
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:892 → 1131
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd03122
      Location:45 → 298
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
      pfam00041
      Location:313 → 401
      fn3; Fibronectin type III domain
      cl17169
      Location:486 → 691
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_024990491.2 → XP_024846259.1  receptor-type tyrosine-protein phosphatase zeta isoform X1

      Conserved Domains (4) summary
      smart00194
      Location:1724 → 1999
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:2058 → 2301
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd03122
      Location:45 → 298
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
      pfam00041
      Location:313 → 401
      fn3; Fibronectin type III domain

    4. XM_010804402.3 → XP_010802704.1  receptor-type tyrosine-protein phosphatase zeta isoform X3

      UniProtKB/TrEMBL
      F1MGK5
      Related
      ENSBTAP00000053776.3, ENSBTAT00000061644.4
      Conserved Domains (4) summary
      smart00194
      Location:1724 → 1999
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1760 → 1999
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd03122
      Location:45 → 298
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
      pfam00041
      Location:313 → 401
      fn3; Fibronectin type III domain

    5. XM_024990492.2 → XP_024846260.1  receptor-type tyrosine-protein phosphatase zeta isoform X2

      Conserved Domains (4) summary
      smart00194
      Location:1724 → 1992
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:2051 → 2294
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd03122
      Location:45 → 298
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
      pfam00041
      Location:313 → 401
      fn3; Fibronectin type III domain

    6. XM_010804403.3 → XP_010802705.1  receptor-type tyrosine-protein phosphatase zeta isoform X4

      Conserved Domains (4) summary
      smart00194
      Location:1724 → 1992
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1753 → 1992
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd03122
      Location:45 → 298
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
      pfam00041
      Location:313 → 401
      fn3; Fibronectin type III domain
    Nucleotide Protein Strain
    Heading Accession and Version

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