PAG2 pregnancy-associated glycoprotein 2 [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: PAG2
Gene description: pregnancy-associated glycoprotein 2
See related: BGD:BT10466; Ensembl:ENSBTAG00000033096
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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Genomic context

Location:: chromosome: 29

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	29	NC_037356.1 (37572051..37581465, complement)

Chromosome 29 - NC_037356.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study examines expression patterns of the genes SERPINA14, PAG, and PAG2 at the fetal-maternal interface in dairy heifers experimentally infected with N caninum during the second trimester of pregnancy, when most abortions takes place in natural conditions.
Title: Crosstalk between uterine serpin (SERPINA14) and pregnancy-associated glycoproteins at the fetal-maternal interface in pregnant dairy heifers experimentally infected with Neospora caninum.
The clinical implications of these findings are that following infection with N. caninum, most cows will experience some level of placental damage and that this injury correlates with foetal fluid PAG levels and pH.
Title: Experimental Neospora Caninum Infection in Pregnant Dairy Heifers Raises Concentrations of Pregnancy-Associated Glycoproteins 1 and 2 in Foetal Fluids.
These findings indicate that IFN-gamma production correlates negatively and the production of antibodies against N. caninum is uncorrelated with plasma pregnancy-associated glycoproteins levels.
Title: Gamma interferon production and plasma concentrations of pregnancy-associated glycoproteins 1 and 2 in gestating dairy cows naturally infected with Neospora caninum.
plasma pregnancy-associated glycoprotein-2 concentrations measured using anti-bovine pregnancy-associated glycoprotein-2 antiserum on Day 120 of gestation could serve as an indicator of the abortion risk in Neospora caninum infected animals
Title: Plasma concentrations of pregnancy-associated glycoproteins measured using anti-bovine PAG-2 antibodies on day 120 of gestation predict abortion in dairy cows naturally infected with Neospora caninum.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: pregnancy-associated glycoprotein 2

Names: PAG 2

NP_788787.1

EC 3.4.23.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176614.1 → NP_788787.1 pregnancy-associated glycoprotein 2 precursor

See identical proteins and their annotated locations for NP_788787.1

Status: PROVISIONAL

Source sequence(s)

L06151

UniProtKB/Swiss-Prot

Q28057

UniProtKB/TrEMBL

Q9TTW1

Related

ENSBTAP00070047929.1, ENSBTAT00070078744.1

Conserved Domains (3) summary

pfam00026
Location:67 → 375

Asp; Eukaryotic aspartyl protease

pfam07966
Location:16 → 44

A1_Propeptide; A1 Propeptide

cl11403
Location:59 → 374

pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases