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    PER2 period circadian regulator 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 512237, updated on 27-Dec-2024

    Summary

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    Official Symbol
    PER2provided by VGNC
    Official Full Name
    period circadian regulator 2provided by VGNC
    Primary source
    VGNC:VGNC:106859
    See related
    BGD:BT24722; Ensembl:ENSBTAG00000001879
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Summary
    This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]
    Orthologs
    human mouse all
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    Genomic context

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    See PER2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (117557012..117599734, complement)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene ILK associated serine/threonine phosphatase Neighboring gene uncharacterized LOC132344956 Neighboring gene hes family bHLH transcription factor 6 Neighboring gene uncharacterized LOC132344957 Neighboring gene TRAF3 interacting protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Circadian Clock genes Per2 and clock regulate steroid production, cell proliferation, and luteinizing hormone receptor transcription in ovarian granulosa cells. Shimizu T, et al. Biochem Biophys Res Commun, 2011 Aug 19. PMID 21819971
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these data provide a new insight that Per2 and Clock have different action on ovarian granulosa cell functions.
      Title: Circadian Clock genes Per2 and clock regulate steroid production, cell proliferation, and luteinizing hormone receptor transcription in ovarian granulosa cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables transcription cis-regulatory region binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription corepressor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in circadian regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in entrainment of circadian clock by photoperiod IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    period circadian protein homolog 2
    Names
    period circadian clock 2
    period homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192317.1 → NP_001179246.1  period circadian protein homolog 2

      See identical proteins and their annotated locations for NP_001179246.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000003
      UniProtKB/TrEMBL
      F1N4I4, G3N0M5
      Conserved Domains (4) summary
      cd00130
      Location:333 → 434
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam12114
      Location:1080 → 1251
      Period_C; Period protein 2/3C-terminal region
      cl26386
      Location:538 → 716
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
      cl26464
      Location:822 → 1059
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      117557012..117599734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024987696.2 → XP_024843464.1  period circadian protein homolog 2 isoform X1

      UniProtKB/TrEMBL
      F1N4I4
      Related
      ENSBTAP00000002448.6, ENSBTAT00000002448.7
      Conserved Domains (4) summary
      cd00130
      Location:327 → 428
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam12114
      Location:1074 → 1245
      Period_C; Period protein 2/3C-terminal region
      cl26386
      Location:532 → 710
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
      cl26464
      Location:816 → 1053
      Atrophin-1; Atrophin-1 family

    2. XM_024987697.2 → XP_024843465.1  period circadian protein homolog 2 isoform X2

      UniProtKB/TrEMBL
      F1N4I4, G3N0M5
      Related
      ENSBTAP00000055391.2, ENSBTAT00000063277.3
      Conserved Domains (4) summary
      cd00130
      Location:333 → 434
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam12114
      Location:1080 → 1251
      Period_C; Period protein 2/3C-terminal region
      cl26386
      Location:538 → 716
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
      cl26464
      Location:822 → 1059
      Atrophin-1; Atrophin-1 family

    3. XM_059883534.1 → XP_059739517.1  period circadian protein homolog 2 isoform X3

      UniProtKB/TrEMBL
      F1N4I4
    Nucleotide Protein Strain
    Heading Accession and Version

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