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    LANCL1 LanC like glutathione S-transferase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 540559, updated on 29-Jan-2025

    Summary

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    Official Symbol
    LANCL1provided by VGNC
    Official Full Name
    LanC like glutathione S-transferase 1provided by VGNC
    Primary source
    VGNC:VGNC:30783
    See related
    BGD:BT24763; Ensembl:ENSBTAG00000015066
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    p40
    Orthologs
    human mouse all
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    Genomic context

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    See LANCL1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (98188209..98237626, complement)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene ninjurin-1-like Neighboring gene myosin light chain 1 Neighboring gene carbamoyl-phosphate synthase 1 Neighboring gene small ribosomal subunit protein eS17-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Identification of lanthionine synthase C-like protein-1 as a prominent glutathione binding protein expressed in the mammalian central nervous system. Chung CH, et al. Biochemistry, 2007 Mar 20. PMID 17305318
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate LanCL1 is a glutathione binding protein possibly significant to neurodegenerative disease.
      Title: Identification of lanthionine synthase C-like protein-1 as a prominent glutathione binding protein expressed in the mammalian central nervous system.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC137731

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptide modification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutathione S-transferase LANCL1
    Names
    40 kDa erythrocyte membrane protein
    LanC lantibiotic synthetase component C-like 1
    LanC like 1
    lanC-like protein 1
    lanthionine synthase C-like protein-1
    NP_001069695.1
    XP_010800568.1
    XP_010800569.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076227.1 → NP_001069695.1  glutathione S-transferase LANCL1

      See identical proteins and their annotated locations for NP_001069695.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115991
      UniProtKB/TrEMBL
      A0AAF6Z0W3
      Conserved Domains (2) summary
      cd04794
      Location:61 → 395
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:1 → 89
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      98188209..98237626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010802267.4 → XP_010800569.1  glutathione S-transferase LANCL1 isoform X1

      See identical proteins and their annotated locations for XP_010800569.1

      UniProtKB/Swiss-Prot
      F1MVX2, Q1LZH8
      UniProtKB/TrEMBL
      A0AAF6Z0W3
      Conserved Domains (2) summary
      cd04794
      Location:61 → 395
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:1 → 89
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    2. XM_010802266.4 → XP_010800568.1  glutathione S-transferase LANCL1 isoform X1

      See identical proteins and their annotated locations for XP_010800568.1

      UniProtKB/Swiss-Prot
      F1MVX2, Q1LZH8
      UniProtKB/TrEMBL
      A0AAF6Z0W3
      Related
      ENSBTAP00070002784.1, ENSBTAT00070004958.1
      Conserved Domains (2) summary
      cd04794
      Location:61 → 395
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:1 → 89
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1MVX2.2 GenPept UniProtKB/Swiss-Prot:F1MVX2

    Gene LinkOut

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