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    FLT4 fms related receptor tyrosine kinase 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 338031, updated on 29-Jan-2025

    Summary

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    Official Symbol
    FLT4provided by VGNC
    Official Full Name
    fms related receptor tyrosine kinase 4provided by VGNC
    Primary source
    VGNC:VGNC:29044
    See related
    BGD:BT10135; Ensembl:ENSBTAG00000001462
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See FLT4 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (496623..537882)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100125913 Neighboring gene 5S ribosomal RNA Neighboring gene CCR4-NOT transcription complex subunit 6 Neighboring gene transfer RNA histidin (anticodon AUG) Neighboring gene glutamine-fructose-6-phosphate transaminase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity. Pepper MS, et al. J Cell Physiol, 1998 Dec. PMID 9808152
    2. The urokinase plasminogen activator system components are regulated by vascular endothelial growth factor D in bovine oviduct. García DC, et al. Zygote, 2018 Jun. PMID 29880066
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FLT4 (VEGFR3) expression in the oviducts.
      Title: The urokinase plasminogen activator system components are regulated by vascular endothelial growth factor D in bovine oviduct.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vascular endothelial growth factor receptor 3
    Names
    fms related tyrosine kinase 4
    XP_010804757.2
    XP_024850494.1
    XP_024850495.1
    XP_059744470.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      496623..537882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010806455.3 → XP_010804757.2  vascular endothelial growth factor receptor 3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SVL9, F1MHP5
      Related
      ENSBTAP00070009887.1, ENSBTAT00070017045.1
      Conserved Domains (6) summary
      cd05862
      Location:248 → 332
      Ig_VEGFR; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
      smart00408
      Location:697 → 759
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:575 → 661
      IG; Immunoglobulin
      pfam13895
      Location:140 → 227
      Ig_2; Immunoglobulin domain
      cl11960
      Location:355 → 421
      Ig; Immunoglobulin domain
      cl21453
      Location:841 → 1180
      PKc_like; Protein Kinases, catalytic domain

    2. XM_024994727.2 → XP_024850495.1  vascular endothelial growth factor receptor 3 isoform X3

      UniProtKB/TrEMBL
      A0AAA9SVL9
      Conserved Domains (6) summary
      cd05862
      Location:248 → 332
      Ig_VEGFR; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
      smart00408
      Location:697 → 759
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:575 → 661
      IG; Immunoglobulin
      pfam13895
      Location:140 → 227
      Ig_2; Immunoglobulin domain
      cl11960
      Location:355 → 421
      Ig; Immunoglobulin domain
      cl21453
      Location:841 → 1180
      PKc_like; Protein Kinases, catalytic domain

    3. XM_024994726.2 → XP_024850494.1  vascular endothelial growth factor receptor 3 isoform X2

      UniProtKB/TrEMBL
      A0AAA9SVL9
      Conserved Domains (5) summary
      cd05862
      Location:248 → 332
      Ig_VEGFR; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
      smart00408
      Location:696 → 758
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:574 → 660
      IG; Immunoglobulin
      cl11960
      Location:355 → 421
      Ig; Immunoglobulin domain
      cl21453
      Location:840 → 1179
      PKc_like; Protein Kinases, catalytic domain

    4. XM_059888487.1 → XP_059744470.1  vascular endothelial growth factor receptor 3 isoform X4

      UniProtKB/TrEMBL
      A0AAA9SVL9
      Related
      ENSBTAP00070009907.1, ENSBTAT00070017058.1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001191344.1: Suppressed sequence

      Description
      NM_001191344.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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