U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ULK1 unc-51 like autophagy activating kinase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 526310, updated on 1-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    ULK1provided by VGNC
    Official Full Name
    unc-51 like autophagy activating kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:36658
    See related
    BGD:BT26556; Ensembl:ENSBTAG00000012987
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ULK1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (45176727..45199649, complement)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112442032 Neighboring gene pseudouridine synthase 1 Neighboring gene matrix metallopeptidase 17 Neighboring gene splicing factor SWAP Neighboring gene microRNA mir-2285af-2

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in autophagy of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in axon extension IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of collateral sprouting IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in piecemeal microautophagy of the nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to starvation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in reticulophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in phagophore assembly site IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    serine/threonine-protein kinase ULK1
    Names
    unc-51-like kinase 1
    NP_001192856.1
    XP_010812125.1
    XP_010812126.1
    XP_010812127.1
    XP_010812128.1
    XP_024833068.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205927.1 → NP_001192856.1  serine/threonine-protein kinase ULK1

      See identical proteins and their annotated locations for NP_001192856.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000017
      UniProtKB/TrEMBL
      A0AAA9SBK8
      Related
      ENSBTAP00000080858.1, ENSBTAT00000092460.1
      Conserved Domains (3) summary
      smart00220
      Location:16 → 278
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14202
      Location:13 → 279
      STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
      pfam12063
      Location:842 → 1049
      DUF3543; Domain of unknown function (DUF3543)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      45176727..45199649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010813825.4 → XP_010812127.1  serine/threonine-protein kinase ULK1 isoform X3

      UniProtKB/TrEMBL
      A0AAA9SBK8, F1MFB2
      Related
      ENSBTAP00000017268.7, ENSBTAT00000017268.7
      Conserved Domains (3) summary
      smart00220
      Location:16 → 278
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14202
      Location:13 → 279
      STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
      pfam12063
      Location:842 → 1061
      DUF3543; Domain of unknown function (DUF3543)

    2. XM_010813824.3 → XP_010812126.1  serine/threonine-protein kinase ULK1 isoform X2

      UniProtKB/TrEMBL
      A0AAA9SBK8
      Conserved Domains (3) summary
      smart00220
      Location:16 → 278
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14202
      Location:13 → 279
      STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
      pfam12063
      Location:861 → 1068
      DUF3543; Domain of unknown function (DUF3543)

    3. XM_010813823.4 → XP_010812125.1  serine/threonine-protein kinase ULK1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SBK8
      Conserved Domains (3) summary
      smart00220
      Location:16 → 278
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14202
      Location:13 → 279
      STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
      pfam12063
      Location:861 → 1080
      DUF3543; Domain of unknown function (DUF3543)

    4. XM_024977300.2 → XP_024833068.1  serine/threonine-protein kinase ULK1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1NIS1
      Conserved Domains (2) summary
      pfam12063
      Location:828 → 1047
      DUF3543; Domain of unknown function (DUF3543)
      cl21453
      Location:49 → 246
      PKc_like; Protein Kinases, catalytic domain

    5. XM_010813826.4 → XP_010812128.1  serine/threonine-protein kinase ULK1 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1NIS1
      Conserved Domains (3) summary
      smart00220
      Location:1 → 172
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12063
      Location:755 → 974
      DUF3543; Domain of unknown function (DUF3543)
      cl21453
      Location:1 → 173
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.