U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MID1 midline 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 534604, updated on 29-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    MID1provided by VGNC
    Official Full Name
    midline 1provided by VGNC
    Primary source
    VGNC:VGNC:31464
    See related
    BGD:BT21365; Ensembl:ENSBTAG00000010152
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MID1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (132157308..132306723)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene MSL complex subunit 3 Neighboring gene Rho GTPase activating protein 6 Neighboring gene uncharacterized LOC104970453 Neighboring gene chloride voltage-gated channel 4 Neighboring gene WWC family member 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Widely spaced alternative promoters, conserved between human and rodent, control expression of the Opitz syndrome gene MID1. Landry JR, et al. Genomics, 2002 Nov. PMID 12408967
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    E3 ubiquitin-protein ligase Midline-1
    Names
    midline 1 (Opitz/BBB syndrome)
    NP_001179751.1
    XP_005228529.1
    XP_005228535.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192822.1 → NP_001179751.1  E3 ubiquitin-protein ligase Midline-1

      See identical proteins and their annotated locations for NP_001179751.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000030
      UniProtKB/TrEMBL
      E1BAD8
      Conserved Domains (7) summary
      smart00502
      Location:219 → 344
      BBC; B-Box C-terminal domain
      cd00063
      Location:381 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12892
      Location:485 → 661
      SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59
      cd16753
      Location:8 → 61
      RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
      cd19822
      Location:168 → 214
      Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
      cd19836
      Location:115 → 164
      Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
      pfam18568
      Location:323 → 374
      COS; TRIM C-terminal subgroup One Signature domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      132157308..132306723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005228472.5 → XP_005228529.1  E3 ubiquitin-protein ligase Midline-1 isoform X1

      See identical proteins and their annotated locations for XP_005228529.1

      UniProtKB/TrEMBL
      E1BAD8
      Related
      ENSBTAP00070036412.1, ENSBTAT00070061179.1
      Conserved Domains (7) summary
      smart00502
      Location:219 → 344
      BBC; B-Box C-terminal domain
      cd00063
      Location:381 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12892
      Location:485 → 661
      SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59
      cd16753
      Location:8 → 61
      RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
      cd19822
      Location:168 → 214
      Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
      cd19836
      Location:115 → 164
      Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
      pfam18568
      Location:323 → 374
      COS; TRIM C-terminal subgroup One Signature domain

    2. XM_005228478.5 → XP_005228535.1  E3 ubiquitin-protein ligase Midline-1 isoform X2

      See identical proteins and their annotated locations for XP_005228535.1

      UniProtKB/TrEMBL
      A0A3Q1N0B4, E1BAD8
      Conserved Domains (6) summary
      smart00502
      Location:182 → 306
      BBC; B-Box C-terminal domain
      cd00063
      Location:343 → 443
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12892
      Location:447 → 623
      SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59
      cd16753
      Location:8 → 61
      RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
      cd19836
      Location:115 → 164
      Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
      pfam18568
      Location:285 → 336
      COS; TRIM C-terminal subgroup One Signature domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials