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    DMGDH dimethylglycine dehydrogenase [ Bos taurus (domestic cattle) ]

    Gene ID: 504453, updated on 27-Dec-2024

    Summary

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    Official Symbol
    DMGDHprovided by VGNC
    Official Full Name
    dimethylglycine dehydrogenaseprovided by VGNC
    Primary source
    VGNC:VGNC:28106
    See related
    BGD:BT30036; Ensembl:ENSBTAG00000002110
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DMGDH in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (10064824..10142808, complement)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346300 Neighboring gene arylsulfatase B Neighboring gene betaine--homocysteine S-methyltransferase 2 Neighboring gene betaine--homocysteine S-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables dimethylglycine dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dimethylglycine dehydrogenase, mitochondrial
    NP_001192474.1
    XP_059746237.1
    XP_059746238.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205545.2 → NP_001192474.1  dimethylglycine dehydrogenase, mitochondrial

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000010
      UniProtKB/TrEMBL
      A0A3Q1MXD4
      Related
      ENSBTAP00000057752.2, ENSBTAT00000067327.2
      Conserved Domains (6) summary
      COG0404
      Location:464 → 856
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      COG0665
      Location:47 → 435
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
      pfam01571
      Location:482 → 745
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:753 → 845
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
      pfam13450
      Location:54 → 106
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      pfam16350
      Location:419 → 472
      FAO_M; FAD dependent oxidoreductase central domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      10064824..10142808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059890254.1 → XP_059746237.1  dimethylglycine dehydrogenase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0AAA9TED2

    2. XM_059890255.1 → XP_059746238.1  dimethylglycine dehydrogenase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MXD4
      Related
      ENSBTAP00000060356.1, ENSBTAT00000082818.2
    Nucleotide Protein Strain
    Heading Accession and Version

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