U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DLG3 discs large MAGUK scaffold protein 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 509882, updated on 1-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    DLG3provided by VGNC
    Official Full Name
    discs large MAGUK scaffold protein 3provided by VGNC
    Primary source
    VGNC:VGNC:56704
    See related
    BGD:BT15838; Ensembl:ENSBTAG00000011291
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See DLG3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (79947017..80000660, complement)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene testis expressed 11 Neighboring gene small nucleolar RNA U2-30 Neighboring gene small nucleolar RNA U2-19 Neighboring gene uncharacterized LOC101904691 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 2 Neighboring gene kinesin family member 4A Neighboring gene zinc finger protein Pegasus-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in embryo development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor clustering IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor localization to synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    disks large homolog 3
    Names
    membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192236.1 → NP_001179165.1  disks large homolog 3

      See identical proteins and their annotated locations for NP_001179165.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000030
      UniProtKB/TrEMBL
      A0A3Q1LYJ6, E1BLW4
      Related
      ENSBTAP00000062340.2, ENSBTAT00000077489.2
      Conserved Domains (5) summary
      cd12029
      Location:502 → 568
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:384 → 462
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:626 → 804
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:311 → 385
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:52 → 130
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      79947017..80000660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010821843.4 → XP_010820145.1  disks large homolog 3 isoform X3

      UniProtKB/TrEMBL
      E1BLW4
      Related
      ENSBTAP00000015000.6, ENSBTAT00000015000.7
      Conserved Domains (5) summary
      cd12029
      Location:502 → 568
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:384 → 462
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:640 → 818
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:311 → 385
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:52 → 130
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    2. XM_010821842.4 → XP_010820144.1  disks large homolog 3 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1M7C6, A0AAA9TFX6
      Related
      ENSBTAP00000066272.1, ENSBTAT00000074695.2
      Conserved Domains (6) summary
      cd12029
      Location:502 → 568
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      smart00072
      Location:655 → 822
      GuKc; Guanylate kinase homologues
      cd00992
      Location:384 → 462
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:644 → 822
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:311 → 385
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:52 → 130
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    3. XM_024987855.2 → XP_024843623.1  disks large homolog 3 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MBH0, A0AAA9TFX6
      Related
      ENSBTAP00000067626.1, ENSBTAT00000084144.2
      Conserved Domains (5) summary
      cd12029
      Location:502 → 568
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:384 → 462
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:658 → 836
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:311 → 385
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:52 → 130
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    4. XM_005228001.5 → XP_005228058.1  disks large homolog 3 isoform X4

      See identical proteins and their annotated locations for XP_005228058.1

      UniProtKB/TrEMBL
      A0AAA9SDS2, A0AAA9T8V0
      Related
      ENSBTAP00000093048.1, ENSBTAT00000091170.1
      Conserved Domains (3) summary
      cd00992
      Location:47 → 125
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:321 → 499
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:165 → 231
      SH3; Src Homology 3 domain superfamily

    5. XM_005228002.5 → XP_005228059.1  disks large homolog 3 isoform X5

      See identical proteins and their annotated locations for XP_005228059.1

      UniProtKB/TrEMBL
      A0AAA9SQH7
      Related
      ENSBTAP00000087613.1, ENSBTAT00000113348.1
      Conserved Domains (2) summary
      pfam00625
      Location:175 → 353
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:19 → 85
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials