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    BRWD1 bromodomain and WD repeat domain containing 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 540661, updated on 27-Dec-2024

    Summary

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    Official Symbol
    BRWD1provided by VGNC
    Official Full Name
    bromodomain and WD repeat domain containing 1provided by VGNC
    Primary source
    VGNC:VGNC:26575
    See related
    BGD:BT30428; Ensembl:ENSBTAG00000013602
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See BRWD1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (139238832..139362519, complement)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene ATPase secretory pathway Ca2+ transporting 1 Neighboring gene proteasome assembly chaperone 1 Neighboring gene ribosomal protein L10a pseudogene Neighboring gene uncharacterized LOC132345905 Neighboring gene high mobility group nucleosome binding domain 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159654

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bromodomain and WD repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103174.2 → NP_001096644.1  bromodomain and WD repeat-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001096644.1

      Status: VALIDATED

      Source sequence(s)
      DV848547, DY195028, EH137476, EH138768, EV626973, NKLS02000001
      UniProtKB/TrEMBL
      A0AAA9TGB5, F1MTQ0
      Related
      ENSBTAP00000018087.6, ENSBTAT00000018087.6
      Conserved Domains (6) summary
      cd05496
      Location:1314 → 1432
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:1149 → 1264
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      COG2319
      Location:185 → 540
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:178 → 497
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05793
      Location:1720 → 2050
      TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
      sd00039
      Location:189 → 226
      7WD40; WD40 repeat [structural motif]

    2. NM_001354349.1 → NP_001341278.1  bromodomain and WD repeat-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC142396, EH138768
      UniProtKB/TrEMBL
      A0AAA9SUH3, A5PK84
      Related
      ENSBTAP00000090100.1, ENSBTAT00000109039.1

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      139238832..139362519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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