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    APBB2 amyloid beta precursor protein binding family B member 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 514013, updated on 27-Dec-2024

    Summary

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    Official Symbol
    APBB2provided by VGNC
    Official Full Name
    amyloid beta precursor protein binding family B member 2provided by VGNC
    Primary source
    VGNC:VGNC:26005
    See related
    BGD:BT11681; Ensembl:ENSBTAG00000027569
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See APBB2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (59711754..60095779, complement)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 47 Neighboring gene uncharacterized LOC104968867 Neighboring gene NOP2/Sun RNA methyltransferase family member 7 Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene ubiquitin C-terminal hydrolase L1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC139640

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    amyloid beta precursor protein binding family B member 2
    Names
    amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)
    amyloid beta A4 precursor protein-binding, family B, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076847.1 → NP_001070315.1  amyloid beta precursor protein binding family B member 2

      See identical proteins and their annotated locations for NP_001070315.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123464
      UniProtKB/TrEMBL
      A0A3Q1MIA1, Q08E17
      Related
      ENSBTAP00000069418.2, ENSBTAT00000074557.2
      Conserved Domains (3) summary
      smart00456
      Location:290 → 321
      WW; Domain with 2 conserved Trp (W) residues
      cd01271
      Location:582 → 708
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:415 → 554
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      59711754..60095779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059887472.1 → XP_059743455.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MIA1, F1MDE6

    2. XM_059887475.1 → XP_059743458.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MIA1, F1MDE6
      Related
      ENSBTAP00000039437.5, ENSBTAT00000039647.6

    3. XM_059887478.1 → XP_059743461.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MIA1, F1MDE6

    4. XM_024993182.2 → XP_024848950.1  amyloid beta precursor protein binding family B member 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MIA1
      Conserved Domains (3) summary
      smart00456
      Location:289 → 320
      WW; Domain with 2 conserved Trp (W) residues
      cd01271
      Location:580 → 706
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:414 → 551
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

    5. XM_059887480.1 → XP_059743463.1  amyloid beta precursor protein binding family B member 2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MIA1

    6. XM_024993181.2 → XP_024848949.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MIA1, F1MDE6
      Conserved Domains (3) summary
      smart00456
      Location:290 → 321
      WW; Domain with 2 conserved Trp (W) residues
      cd01271
      Location:581 → 707
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:415 → 552
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

    7. XM_059887481.1 → XP_059743464.1  amyloid beta precursor protein binding family B member 2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MIA1

    8. XM_059887476.1 → XP_059743459.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MIA1, F1MDE6

    9. XM_005207868.5 → XP_005207925.1  amyloid beta precursor protein binding family B member 2 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1MIA1
      Conserved Domains (3) summary
      smart00456
      Location:289 → 320
      WW; Domain with 2 conserved Trp (W) residues
      cd01271
      Location:558 → 684
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:393 → 530
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

    10. XM_010806070.4 → XP_010804372.1  amyloid beta precursor protein binding family B member 2 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1MIA1
      Conserved Domains (3) summary
      smart00456
      Location:289 → 320
      WW; Domain with 2 conserved Trp (W) residues
      cd01271
      Location:559 → 685
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:393 → 530
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

    11. XM_005207865.5 → XP_005207922.1  amyloid beta precursor protein binding family B member 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MIA1
      Conserved Domains (3) summary
      smart00456
      Location:289 → 320
      WW; Domain with 2 conserved Trp (W) residues
      cd01271
      Location:580 → 706
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:414 → 551
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

    12. XM_005207867.5 → XP_005207924.1  amyloid beta precursor protein binding family B member 2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MIA1
      Conserved Domains (3) summary
      smart00456
      Location:290 → 321
      WW; Domain with 2 conserved Trp (W) residues
      cd01271
      Location:560 → 686
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:394 → 531
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

    13. XM_059887479.1 → XP_059743462.1  amyloid beta precursor protein binding family B member 2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MIA1

    14. XM_005207864.5 → XP_005207921.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MIA1, F1MDE6
      Conserved Domains (3) summary
      smart00456
      Location:290 → 321
      WW; Domain with 2 conserved Trp (W) residues
      cd01271
      Location:581 → 707
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:415 → 552
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

    15. XM_059887474.1 → XP_059743457.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MIA1, F1MDE6

    16. XM_059887473.1 → XP_059743456.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MIA1, F1MDE6

    17. XM_059887477.1 → XP_059743460.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MIA1, F1MDE6

    18. XM_059887482.1 → XP_059743465.1  amyloid beta precursor protein binding family B member 2 isoform X8

    19. XM_024993184.2 → XP_024848952.1  amyloid beta precursor protein binding family B member 2 isoform X7

      Conserved Domains (1) summary
      cd01271
      Location:34 → 160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

    20. XM_059887483.1 → XP_059743466.1  amyloid beta precursor protein binding family B member 2 isoform X7

    21. XM_005207871.5 → XP_005207928.1  amyloid beta precursor protein binding family B member 2 isoform X7

      See identical proteins and their annotated locations for XP_005207928.1

      Conserved Domains (1) summary
      cd01271
      Location:34 → 160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

    22. XM_005207870.5 → XP_005207927.1  amyloid beta precursor protein binding family B member 2 isoform X10

      See identical proteins and their annotated locations for XP_005207927.1

      Conserved Domains (2) summary
      cd01271
      Location:89 → 215
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cl17171
      Location:14 → 60
      PH-like; Pleckstrin homology-like domain

    23. XM_005207869.5 → XP_005207926.1  amyloid beta precursor protein binding family B member 2 isoform X9

      See identical proteins and their annotated locations for XP_005207926.1

      Conserved Domains (2) summary
      cd01271
      Location:92 → 218
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cl17171
      Location:19 → 63
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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