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    UBE2K ubiquitin conjugating enzyme E2 K [ Bos taurus (domestic cattle) ]

    Gene ID: 281225, updated on 27-Dec-2024

    Summary

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    Official Symbol
    UBE2Kprovided by VGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 Kprovided by VGNC
    Primary source
    VGNC:VGNC:36587
    See related
    BGD:BT11428; Ensembl:ENSBTAG00000020175
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    LIG; HIP2; HYPG; E2-25K
    Orthologs
    human mouse all
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    Genomic context

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    See UBE2K in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (58774603..58854233)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene UDP-glucose 6-dehydrogenase Neighboring gene small integral membrane protein 14 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene PDS5 cohesin associated factor A Neighboring gene nucleosome assembly protein 1-like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Core domain mutation (S86Y) selectively inactivates polyubiquitin chain synthesis catalyzed by E2-25K. Mastrandrea LD, et al. Biochemistry, 1998 Jul 7. PMID 9657692
    2. Structure and function of ubiquitin conjugating enzyme E2-25K: the tail is a core-dependent activity element. Haldeman MT, et al. Biochemistry, 1997 Aug 26. PMID 9265633
    3. Isolation of a cDNA encoding a mammalian multiubiquitinating enzyme (E225K) and overexpression of the functional enzyme in Escherichia coli. Chen ZJ, et al. J Biol Chem, 1991 Aug 25. PMID 1714895
    4. Structure of a diubiquitin conjugate and a model for interaction with ubiquitin conjugating enzyme (E2). Cook WJ, et al. J Biol Chem, 1992 Aug 15. PMID 1322903
    5. SUMO modification of the ubiquitin-conjugating enzyme E2-25K. Pichler A, et al. Nat Struct Mol Biol, 2005 Mar. PMID 15723079

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 K
    Names
    E2 ubiquitin-conjugating enzyme K
    E2(25K)
    HIP-2
    huntingtin interacting protein 2
    ubiquitin carrier protein
    ubiquitin-conjugating enzyme E2-25 kDa
    ubiquitin-conjugating enzyme E2-25K
    ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
    ubiquitin-protein ligase
    NP_776505.1
    XP_024848745.1
    XP_024848746.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174080.2 → NP_776505.1  ubiquitin-conjugating enzyme E2 K

      See identical proteins and their annotated locations for NP_776505.1

      Status: PROVISIONAL

      Source sequence(s)
      S51016
      UniProtKB/TrEMBL
      A0AAA9S8T0
      Related
      ENSBTAP00000078565.1, ENSBTAT00000112751.1
      Conserved Domains (3) summary
      COG5078
      Location:1 → 153
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:6 → 149
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cd14390
      Location:163 → 200
      UBA_II_E2_UBE2K; UBA domain of vertebrate ubiquitin-conjugating enzyme E2 K (UBE2K)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      58774603..58854233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024992977.2 → XP_024848745.1  ubiquitin-conjugating enzyme E2 K isoform X1

      UniProtKB/TrEMBL
      A0AAF6Z802
      Related
      ENSBTAP00000026871.6, ENSBTAT00000026871.7
      Conserved Domains (2) summary
      smart00212
      Location:22 → 103
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
      cl21463
      Location:112 → 149
      UBA_like_SF; UBA domain-like superfamily

    2. XM_024992978.2 → XP_024848746.1  ubiquitin-conjugating enzyme E2 K isoform X2

      Conserved Domains (2) summary
      cl00154
      Location:1 → 51
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cl21463
      Location:60 → 97
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61085.3 GenPept UniProtKB/Swiss-Prot:P61085

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