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    MAEA macrophage erythroblast attacher, E3 ubiquitin ligase [ Bos taurus (domestic cattle) ]

    Gene ID: 511956, updated on 29-Jan-2025

    Summary

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    Official Symbol
    MAEAprovided by VGNC
    Official Full Name
    macrophage erythroblast attacher, E3 ubiquitin ligaseprovided by VGNC
    Primary source
    VGNC:VGNC:31135
    See related
    BGD:BT22921; Ensembl:ENSBTAG00000012575
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MAEA in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (117125130..117152555, complement)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene NK1 homeobox 1 Neighboring gene UV stimulated scaffold protein A Neighboring gene uncharacterized LOC101904569 Neighboring gene uncharacterized LOC100299277 Neighboring gene C-terminal binding protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC128694

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GID complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein transferase MAEA
    NP_001029587.1
    XP_024848934.1
    XP_024848936.1
    XP_059743447.1
    XP_059743448.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034415.1 → NP_001029587.1  E3 ubiquitin-protein transferase MAEA

      See identical proteins and their annotated locations for NP_001029587.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105218
      UniProtKB/Swiss-Prot
      A7E3P9, Q3MHJ2
      UniProtKB/TrEMBL
      A0AAA9RU03
      Related
      ENSBTAP00070000080.1, ENSBTAT00070000134.1
      Conserved Domains (5) summary
      smart00667
      Location:120 → 153
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:159 → 254
      CTLH; C-terminal to LisH motif
      smart00757
      Location:250 → 342
      CRA; CT11-RanBPM
      pfam10607
      Location:160 → 339
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      pfam13445
      Location:378 → 417
      zf-RING_UBOX; RING-type zinc-finger

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      117125130..117152555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024993166.2 → XP_024848934.1  E3 ubiquitin-protein transferase MAEA isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LTS7
      Related
      ENSBTAP00070000081.1, ENSBTAT00070000135.1
      Conserved Domains (3) summary
      smart00667
      Location:120 → 153
      LisH; Lissencephaly type-1-like homology motif
      pfam10607
      Location:160 → 301
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cd16659
      Location:336 → 383
      RING-Ubox_Emp; U-box domain, a modified RING finger, found in erythroblast macrophage protein (Emp) and similar proteins

    2. XM_024993168.2 → XP_024848936.1  E3 ubiquitin-protein transferase MAEA isoform X2

      UniProtKB/TrEMBL
      A0AAA9RU03
      Conserved Domains (3) summary
      smart00667
      Location:72 → 105
      LisH; Lissencephaly type-1-like homology motif
      pfam10607
      Location:112 → 291
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cd16659
      Location:326 → 373
      RING-Ubox_Emp; U-box domain, a modified RING finger, found in erythroblast macrophage protein (Emp) and similar proteins

    3. XM_059887464.1 → XP_059743447.1  E3 ubiquitin-protein transferase MAEA isoform X2

      UniProtKB/TrEMBL
      A0AAA9RU03

    4. XM_059887465.1 → XP_059743448.1  E3 ubiquitin-protein transferase MAEA isoform X2

      UniProtKB/TrEMBL
      A0AAA9RU03
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3MHJ2.1 GenPept UniProtKB/Swiss-Prot:Q3MHJ2

    Gene LinkOut

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