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    HPD 4-hydroxyphenylpyruvate dioxygenase [ Bos taurus (domestic cattle) ]

    Gene ID: 516058, updated on 29-Jan-2025

    Summary

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    Official Symbol
    HPDprovided by VGNC
    Official Full Name
    4-hydroxyphenylpyruvate dioxygenaseprovided by VGNC
    Primary source
    VGNC:VGNC:29939
    See related
    BGD:BT21691; Ensembl:ENSBTAG00000004175
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See HPD in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (53458851..53470907)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132342614 Neighboring gene cilia and flagella associated protein 251 Neighboring gene proteasome 26S subunit, non-ATPase 9 Neighboring gene uncharacterized LOC104974641 Neighboring gene SET domain containing 1B, histone lysine methyltransferase Neighboring gene transmembrane protein 120B Neighboring gene ras homolog family member F, filopodia associated

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC128788

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 4-hydroxyphenylpyruvate dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tyrosine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    4-hydroxyphenylpyruvate dioxygenase
    Names
    4-hydroxyphenylpyruvic acid oxidase
    4HPPD
    HPPDase
    NP_001015611.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015611.1 → NP_001015611.1  4-hydroxyphenylpyruvate dioxygenase

      See identical proteins and their annotated locations for NP_001015611.1

      Status: PROVISIONAL

      Source sequence(s)
      BT020749
      UniProtKB/Swiss-Prot
      Q5EA20
      UniProtKB/TrEMBL
      A0A3Q1N2P4
      Related
      ENSBTAP00070036977.1, ENSBTAT00070062053.1
      Conserved Domains (3) summary
      cd07250
      Location:178 → 373
      HPPD_C_like; C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS)
      cd08342
      Location:19 → 162
      HPPD_N_like; N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS)
      TIGR01263
      Location:19 → 381
      4HPPD; 4-hydroxyphenylpyruvate dioxygenase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      53458851..53470907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5EA20.3 GenPept UniProtKB/Swiss-Prot:Q5EA20

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