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    CRTC1 CREB regulated transcription coactivator 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 510465, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CRTC1provided by VGNC
    Official Full Name
    CREB regulated transcription coactivator 1provided by VGNC
    Primary source
    VGNC:VGNC:27728
    See related
    BGD:BT14967; Ensembl:ENSBTAG00000010379
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CRTC1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (4430905..4516054, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112447321 Neighboring gene cartilage oligomeric matrix protein Neighboring gene U6 spliceosomal RNA Neighboring gene kelch like family member 26 Neighboring gene uncharacterized LOC112447594 Neighboring gene transmembrane protein 59 like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Bta-miR-149-5p inhibits proliferation and differentiation of bovine adipocytes through targeting CRTCs at both transcriptional and posttranscriptional levels. Khan R, et al. J Cell Physiol, 2020 Jul. PMID 32003022
    2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bta-miR-149-5p inhibits proliferation and differentiation of bovine adipocytes through targeting CRTCs at both transcriptional and posttranscriptional levels.
      Title: Bta-miR-149-5p inhibits proliferation and differentiation of bovine adipocytes through targeting CRTCs at both transcriptional and posttranscriptional levels.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cAMP response element binding protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of CREB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CREB-regulated transcription coactivator 1
    Names
    mucoepidermoid carcinoma translocated 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206319.2 → NP_001193248.1  CREB-regulated transcription coactivator 1

      Status: VALIDATED

      Source sequence(s)
      BC126489, CB445064, DN538645, NKLS02000007
      UniProtKB/TrEMBL
      F1MQ51
      Related
      ENSBTAP00000073232.2, ENSBTAT00000073312.2
      Conserved Domains (3) summary
      pfam12884
      Location:6 → 66
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:148 → 293
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:527 → 602
      TORC_C; Transducer of regulated CREB activity, C terminus

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      4430905..4516054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005208444.5 → XP_005208501.1  CREB-regulated transcription coactivator 1 isoform X2

      See identical proteins and their annotated locations for XP_005208501.1

      UniProtKB/TrEMBL
      A0A3Q1LQZ0
      Conserved Domains (3) summary
      pfam12884
      Location:6 → 66
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:148 → 293
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:563 → 638
      TORC_C; Transducer of regulated CREB activity, C terminus

    2. XM_005208443.5 → XP_005208500.1  CREB-regulated transcription coactivator 1 isoform X1

      See identical proteins and their annotated locations for XP_005208500.1

      UniProtKB/TrEMBL
      A0A3Q1LQZ0, A0A3Q1N5T5
      Related
      ENSBTAP00000065650.1, ENSBTAT00000070403.2
      Conserved Domains (3) summary
      pfam12884
      Location:6 → 66
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:164 → 309
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:579 → 654
      TORC_C; Transducer of regulated CREB activity, C terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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